- #1
gravenewworld
- 1,132
- 26
I was wondering if any pro chemists on here have a decent amount of experience doing suzuki coupling reactions. Currently I am trying to couple alkyl boronic acids to a bromo pyridine in the microwave, but seem to be having a lot of trouble. The only thing that I am observing so far is removal of the bromo, but no addition of my alkyl chain to the pyridine ring. I was wondering if anyone has any suggestions for what types of palladium catalysts/ligands/bases/temperature/or solvents I should be using for this type of reaction. I make sure before every reaction that I degas the vial with nitrogen to remove any oxygen from the solvent.