To diagnose segmentation faults in applications using gdb, it's essential to understand that segfaults typically occur when a program attempts to access memory it shouldn't, often due to uninitialized pointers or exceeding array boundaries. To effectively identify the specific line causing the fault, users should compile their programs with debugging symbols enabled (using gcc -g) to facilitate better debugging. When a segmentation fault occurs, instead of merely running the program, setting breakpoints and stepping through the code line by line can help pinpoint the issue. Additionally, analyzing core dumps with gdb can provide insights into the program's state at the time of the fault, allowing for further investigation into the cause of the segmentation fault.