To find the derivative of the quadratic function f(x) = -2(x-3)^2 at the point (2, -2), the key steps involve calculating f'(x) = -4(x-3). Evaluating this at x = 2 gives f'(2) = 4, which represents the slope of the tangent line at that point. The point (2, -2) is provided to illustrate the relationship between the derivative and the tangent line, though it may seem unnecessary for this calculation. The discussion also touches on the use of limits and the power rule for finding derivatives, although there are some inaccuracies noted in the application of these concepts. Understanding these principles is crucial for solving similar problems in calculus.