Mammalian Enteral Ventilation - a new way to breathe

  • Thread starter Thread starter Tom.G
  • Start date Start date
  • Tags Tags
    Ventilation
AI Thread Summary
Recent research demonstrates that blood oxygenation can be achieved through the lower intestinal tract in both mice and pigs, potentially offering a new method for temporarily assisting human respiratory function. This enteral ventilation technique draws inspiration from loaches, which utilize intestinal air breathing. The study shows that intra-rectal delivery of a liquid oxygen compound, specifically conjugated perfluorocarbon, is both well-tolerated and effective in treating severe respiratory failure. This innovative approach may pave the way for new clinical applications in respiratory support.
Tom.G
Science Advisor
Gold Member
Messages
5,661
Reaction score
4,504
From: https://www.cell.com/med/fulltext/S2666-6340(21)00153-7?utm_source=EA

Blood oxygenation through the lower intestinal tract is demonstrated in both mice and pigs. It is hoped this wiil work for those Humans that need temporary assistance with respiratory function.

Inspired by organisms such as loaches that use intestinal air breathing, we show the effectiveness of an enteral ventilation approach in attaining systemic oxygenation in both rodent and porcine models. Intra-rectal delivery of a liquid form of O2 known as conjugated perfluorocarbon, a compound historically used in clinics for liquid ventilation through airway administration, is highly tolerable and efficacious in ameliorating severe respiratory failure.
 
Reply
  • Like
  • Informative
Likes BillTre and hmmm27
Biology news on Phys.org

Thread 'Body dysmorphic disorder (BDD)'

https://www.nhs.uk/mental-health/conditions/body-dysmorphia/ Most people have some mild apprehension about their body, such as one thinks their nose is too big, hair too straight or curvy. At the extreme, cases such as this, are difficult to completely understand. https://www.msn.com/en-ca/health/other/why-would-someone-want-to-amputate-healthy-limbs/ar-AA1MrQK7?ocid=msedgntp&cvid=68ce4014b1fe4953b0b4bd22ef471ab9&ei=78 they feel like they're an amputee in the body of a regular person "For...
View full post »
Thread 'Did they discover another descendant of homo erectus?'

Thread 'Did they discover another descendant of homo erectus?'

The study provides critical new insights into the African Humid Period, a time between 14,500 and 5,000 years ago when the Sahara desert was a green savanna, rich in water bodies that facilitated human habitation and the spread of pastoralism. Later aridification turned this region into the world's largest desert. Due to the extreme aridity of the region today, DNA preservation is poor, making this pioneering ancient DNA study all the more significant. Genomic analyses reveal that the...
View full post »

Thread 'Warning of new opiod drug (nitazene) on the streets: Question re strength...'

Whenever these opiods are mentioned they usually mention that e.g. fentanyl is "50 times stronger than heroin" and "100 times stronger than morphine". Now it's nitazene which the public is told is everything from "much stronger than heroin" and "200 times stronger than fentany"! Do these numbers make sense at all? How do they arrive at them? Kill thousands of mice? En passant: nitazene have already been found in both Oxycontin pills and in street "heroin" here, so Naloxone is more...
View full post »

Hot Threads

Recent Insights

Back
Top