Pharmacophore and polarity of aspirin and ibuprofen?

[lalaladucks]

Homework Statement

I need to know the pharmacophore of aspirin (acetylsalicylic acid) and ibuprofen. There is a task where I have to compare these two drugs' structure, synthesis, mechanism of action and side effects.
Specifically, it says to include,

• "The chemical structure of the drug including the pharmacophore (group of atoms which confers the pharmacological activity)"

Homework Equations

I would also like to know about the polarity of the aspirin molecule, and the ibuprofen molecule.
Information regarding these topics would be greatly appreciated :)

The Attempt at a Solution

I've read that the acetyl group in aspirin attached to the serine active site in the body to irreversibly inhibit COX 1 and 2. I know that the functional groups in aspirin are a benzene ring, carboxylic acid group and an ester group, but I'm not too sure how this relates to the pharmacophore.
I haven't been able to find the pharmacophore of aspirin and ibuprofen with research.

 

[Asim Riaz]

I know ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and is an propionic acid derivative, but I'm not sure how this relates to the pharmacophore either. I would also like to know about the polarity of the aspirin molecule, and the ibuprofen molecule.