The bradykinin hypothesis generated by a supercomputer AI

  • Thread starter kadiot
  • Start date
  • Tags
    Ai
In summary, there is currently a lot of attention on the cytokine dysregulation in COVID-19, but bradykinin is just one of many cytokines involved. It is important to better understand its role, along with other immune processes, in order to fully understand the disease. The theory generated by the supercomputer is just a hypothesis and more research is needed to confirm it. Supercomputers may continue to play a role in specialized tasks, but human interpretation and input are still crucial in scientific research.
  • #1
kadiot
282
82
First of all, the cytokine dysregulation ("storm" is such a loaded term, there are degrees - even storms have categories) involves not just bradykinin but a whole host of cytokines including IL-6 and the renin-angiotensin system. It also involves a whole lot of cells including T-cells, macrophages and endothelial cells. The reason why bradykinin is getting a lot of attention is because it seems to have a role ON TOP of all these other things going on. It is by no means the most important part of the response, but we do need to better define its role - along with all the other cytokines and immune processes going on. If it has a more significant role than in other diseases, then that is important and needs to be studied, but this story is by no means solved.

As an example, while bradykinin causes "leaky blood vessels," a major pathophysiologic manifestion of severe COVID-19 is CLOTS. This is what causes the strokes and some of the heart attacks. There are OTHER THINGS causing problems in COVID-19 and bradykinin is just ONE of them.

A supercomputer was used to generste the hypothesis, but the programming and inputs were made and interpreted by humans. I expect supercomputer AI to continue to get better in specialized tasks and act side-by-side with researchers/scientists.https://elemental.medium.com/a-supe...teresting-new-theory-has-emerged-31cb8eba9d63
 
  • Like
Likes Ibix
Technology news on Phys.org
  • #2
Thread closed temporarily for Moderation...
 
  • #3
Last edited by a moderator:
  • Like
Likes berkeman

1. What is the bradykinin hypothesis?

The bradykinin hypothesis is a theory proposed by a supercomputer AI that suggests bradykinin, a small protein found in the body, plays a significant role in the development of severe symptoms in COVID-19 patients.

2. How was this hypothesis generated by a supercomputer AI?

The supercomputer AI analyzed vast amounts of data from COVID-19 patient samples to identify patterns and potential mechanisms involved in the development of severe symptoms. It then generated the bradykinin hypothesis based on its findings.

3. What evidence supports the bradykinin hypothesis?

Several studies have shown elevated levels of bradykinin in COVID-19 patients, as well as genetic variations in the bradykinin pathway that may contribute to severe symptoms. Additionally, the AI's analysis of patient data revealed potential interactions between bradykinin and other molecules involved in the body's response to the virus.

4. How does the bradykinin hypothesis explain severe COVID-19 symptoms?

The hypothesis suggests that bradykinin can cause blood vessels to leak and promote fluid buildup in the lungs, leading to respiratory distress. It may also contribute to inflammation and blood clot formation, which are common in severe COVID-19 cases.

5. What are the implications of the bradykinin hypothesis for COVID-19 treatment?

If the bradykinin hypothesis is confirmed, it could lead to the development of new treatments that target the bradykinin pathway to reduce severe symptoms in COVID-19 patients. It may also provide insights into why some individuals are more susceptible to severe illness and how to identify and treat these patients more effectively.

Similar threads

INKT (Invariant natural killer T cells) as a COVID-19 therapy
    • Biology and Medical
Replies
1
Views
791
COVID SARS-CoV-2 Mutations: B.1.1.7, B.1.351 & D614G Research
    • Biology and Medical
3
Replies
93
Views
14K

Hot Threads

Recent Insights

Back
Top