Understanding DNA Base Pair Alterations: C-G to U-G Mutation and Its Effects

[1MileCrash]

If in a given DNA molecule a C-G base pair is
changed to a U-G base pair the following
mutational change in the DNA will result
a. C-G to G-C
b. C-G to T-A
c. C-G to A-T
d. C-G to A-U

Can someone elaborate on this for me?

 

[aroc91]

That doesn't really make any sense. If a base gets changed to a uracil in DNA, the cell will go "Hey! Uracil doesn't belong in DNA, it belongs in RNA" and would change it back to cytosine. It'd end up being C-G, just as it began.

Seeing as I just covered DNA repair in genetics, none of those answers seem correct to me.

 

[1MileCrash]

Exactly!

 

[mishrashubham]

It is called deamination and a possible answer is b: C-G to T-A.

Check These
http://en.wikipedia.org/wiki/Deamination
http://en.wikipedia.org/wiki/Activation-Induced_(Cytidine)_Deaminase
http://en.wikipedia.org/wiki/Base_excision_repair

 

[LudusRex]

I can provide some insight into this topic. DNA is made up of four different nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C). These bases pair up in a specific way, with A always pairing with T and G always pairing with C. This pairing is essential for maintaining the integrity and function of DNA.

When a C-G base pair is changed to a U-G base pair, it is called a C-G to U-G mutation. This type of mutation is known as a point mutation, as it only affects a single base pair. The result of this mutation can vary depending on the type of change that occurs. The options listed in the statement are possible outcomes of this mutation.

a. C-G to G-C: This is a reversal of the original base pair, where the G now pairs with the C instead of the other way around. This may not have a significant impact on the function of the DNA, as the pairing is still maintained.

b. C-G to T-A: This is a more significant change, as the U (which is equivalent to T in RNA) now pairs with the A instead of the G. This can potentially lead to errors in the genetic code during DNA replication or protein synthesis.

c. C-G to A-T: This is a complete reversal of the base pair, where the A now pairs with the T instead of the G. This can also lead to errors in the genetic code and potentially impact the function of the DNA.

d. C-G to A-U: This is a more drastic change, as the U (which is equivalent to A in RNA) now pairs with the A instead of the G. This can have significant consequences as it can change the genetic code and potentially alter the function of the DNA.

In summary, a C-G to U-G mutation can result in a variety of changes in the DNA, which can have varying effects on its function. It is important to note that any alteration in the DNA sequence can potentially impact the organism's traits and overall health.