Recent content by nymbler_064

Thankyou so much! Your easy to understand explanation has helped me out profusely.

I really like where you are going with this analogy, but am still confused as to why one enantiomer has a higher solubility (sorry, I'm a bit thick...). Or is it merely that each type forms a big crystal with each other, so the two types can be differentiated between? However, that doesn't seem...

I have just been trying to teach myself about the effect of activating and deactivating groups on electrophilic substitution. However, I am a bit confused as to why the amine group in procaine (anesthetic) is in the para position, when the aromatic ring is attached to a deactivating ester. What...

Thanks very much for your detailed and thoughtful response. It helped a lot! I was also just wondering if you knew why S diastereomer salt has a lower solubility that its diastereomeric counterpart, causing it to crystallize?

Thanks so much for this - really appreciated. I just wanted to check, is then when you start with a racemic mixture of both enantinomers of bupivacaine? And the enzyme reacts with one enantiomer, while lidocaine remains? I am a little confused about the specifics of this reaction... EDIT: I...

How would a chemist go about this? For example, how is levobupivacaine synthesized from bupivacaine?

Thanks very much for your response. Would it be true to say that when the drug is manufactured normally, both enantinomers are formed randomly in equal proportions?

Hi Everyone! I am having a little trouble understanding the concept of drug chirality... I know what they are, but am unsure about how they are formed in the first place (is it a random chance that one enantinomer will be formed over the other, can the be specifically created...?). Also, how...

Thanks very much - It seems i need to reevaluate my understanding of its action.

Hi guys, I just have a quick query about the mechanism of action of salicylic acid. I have tried in vain to find a solution elsewhere, but have not had any luck. How exactly does salicyclic acid work. As far as I can tell, it doesn't have an acetyl group, which is how aspirin mediates its...

I'm so sorry - I'm only just starting to learn about organic chemistry. Many thanks for your reply.

I was just wondering if anyone would be able to tell me why acetic acid is reacted with salicylic acid to form aspirin. I am aware that the latter is toxic and that the addition of acetic acid lessens its effects, but what specific properties does acetic acid have that enable it to do so. I have...

I've already done plotted the results of the experiment, and did find an exponential trend. I just wanted to check it could be backed up by theory. :)

Does anyone know if this would be correct? I just need this one last piece of information! Thanks so much.

Thanks so much for all your help! Just to link the exponential trend, could you say that the change in the value of ka is greater at higher temperatures. That is, if you increased the temperature of a system from 50C to 70C, you would see a greater change in the extent of dissociation than from...