Does Salicylic Acid Work by Hydrolyzing to its Active Form?

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Salicylic acid's mechanism of action is distinct from that of aspirin, primarily due to the absence of an acetyl group, which is crucial for aspirin's inhibition of cyclooxygenase (COX) enzymes. While aspirin is hydrolyzed to salicylic acid, the latter does not exert the same effects on COX. The discussion emphasizes the need to reassess the understanding of how salicylic acid functions, particularly in relation to its role as an active metabolite of aspirin. Further exploration of salicylic acid's specific actions and therapeutic uses is encouraged for clarity.
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Hi guys, I just have a quick query about the mechanism of action of salicylic acid. I have tried in vain to find a solution elsewhere, but have not had any luck.

How exactly does salicyclic acid work. As far as I can tell, it doesn't have an acetyl group, which is how aspirin mediates its effects on COX. However, my research seem to suggest that this is the active form of aspirin (ie. Aspirin undergoes hydrolysis to salicylic acid prior to acetalysing COX). Is this true, and if so, how does it work?

Kind Regards.
 
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nymbler_064 said:
Hi guys, I just have a quick query about the mechanism of action of salicylic acid. I have tried in vain to find a solution elsewhere, but have not had any luck.

How exactly does salicyclic acid work. As far as I can tell, it doesn't have an acetyl group, which is how aspirin mediates its effects on COX. However, my research seem to suggest that this is the active form of aspirin (ie. Aspirin undergoes hydrolysis to salicylic acid prior to acetalysing COX). Is this true, and if so, how does it work?

Kind Regards.

You need to alter your understanding of aspirin's mechanism of action perhaps.

http://www.cas.org/newsevents/connections/salicylicacid.html
 
Thanks very much - It seems i need to reevaluate my understanding of its action.
 

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