Using a 50-watt solar panel that outputs 17.4 volts under load to power a 12-volt DC fan can potentially harm the fan due to overvoltage, leading to increased current draw and overheating. The fan's lifespan may be shortened due to higher speeds and vibrations, especially if it is a brushed motor. To mitigate risks, measuring the fan's current draw and considering a voltage regulator to maintain a steady 12 volts is advisable. The fan's performance may vary significantly with sunlight conditions, and using a more suitable fan or additional solar panels could optimize the setup. Overall, careful monitoring and adjustments are essential to ensure the fan operates safely and efficiently.