A baseball accelerates from 0 to 46 m/s in 0.143 seconds, resulting in an average acceleration of approximately 321.1 m/s². The discussion highlights the need to understand the formula for acceleration, which is the change in velocity divided by the time taken. Participants emphasize the importance of starting with known values and applying the correct calculations. Clarification on how to approach the problem is provided, focusing on the basic principles of physics related to acceleration. Understanding these concepts is crucial for solving similar problems effectively.