- #1
Genava
- 69
- 72
Paternal transmission of mitochondrial DNA (mtDNA) may be possible, a new study suggests – contradicting the accepted view that it is passed on exclusively through maternal inheritance.
The find, made by a team led by Taosheng Huang from Cincinnati Children’s Hospital Medical Centre, and Paldeep Atwal, from Mayo Clinic Hospital, Jacksonville, both in the US, may stimulate further study of mtDNA genetics that leads to alternative treatments for mitochondrial diseases.
Writing in the journal Proceedings of the National Academy of Sciences, the researchers present evidence of biparental inheritance of mitochondrial DNA in 17 members of three unrelated multi-generation families. The findings were independently validated using multiple approaches for whole mtDNA sequencing.
“Our results suggest that, although the central dogma of maternal inheritance of mtDNA remains valid, there are some exceptional cases where paternal mtDNA could be passed to the offspring,” they write.
News article: https://cosmosmagazine.com/biology/...s/when-did-mitochondria-evolve/"]mitochondrial-dna[/URL]
PNAS publication:
www.pnas.org/content/early/2018/11/21/1810946115
The find, made by a team led by Taosheng Huang from Cincinnati Children’s Hospital Medical Centre, and Paldeep Atwal, from Mayo Clinic Hospital, Jacksonville, both in the US, may stimulate further study of mtDNA genetics that leads to alternative treatments for mitochondrial diseases.
Writing in the journal Proceedings of the National Academy of Sciences, the researchers present evidence of biparental inheritance of mitochondrial DNA in 17 members of three unrelated multi-generation families. The findings were independently validated using multiple approaches for whole mtDNA sequencing.
“Our results suggest that, although the central dogma of maternal inheritance of mtDNA remains valid, there are some exceptional cases where paternal mtDNA could be passed to the offspring,” they write.
News article: https://cosmosmagazine.com/biology/...s/when-did-mitochondria-evolve/"]mitochondrial-dna[/URL]
PNAS publication:
www.pnas.org/content/early/2018/11/21/1810946115