A diesel engine cannot effectively run on gasoline due to fundamental differences in how each fuel ignites; gasoline requires a spark while diesel ignites through compression. While there are rare instances where a diesel might run on gasoline for a short time, such as when residual diesel fuel is present, it can lead to severe mechanical issues and potential engine damage. The combustion characteristics of diesel and gasoline are opposite, with diesel designed for easy ignition and gasoline for high compression resistance. Experiments are ongoing to create gasoline engines that ignite via compression, but they face challenges, particularly with emissions. Ultimately, using gasoline in a diesel engine is not advisable and can result in significant operational problems.