Can we create life from scratch?

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Discussion Overview

The discussion revolves around the theoretical possibility of creating life from scratch using chemical components. Participants explore definitions of life, the complexities of cellular assembly, and implications for understanding intelligence and self-awareness. The conversation touches on both scientific and philosophical aspects of life creation, including references to historical biological processes and the challenges of replicating them artificially.

Discussion Character

  • Exploratory
  • Debate/contested
  • Conceptual clarification
  • Technical explanation

Main Points Raised

  • Some participants propose that while injecting genetic code into bacteria is significant, it does not equate to creating life from scratch.
  • Others argue that theoretically, assembling the necessary chemicals to create a living cell is possible, although current scientific understanding is limited.
  • A participant suggests that the first artificial cell would not exhibit intelligence or self-awareness, similar to unicellular organisms.
  • There is a discussion about the role of a womb in creating life, with some asserting that it uses existing living cells rather than creating life from non-living components.
  • One participant mentions that viruses have been synthesized in cell-free systems, which raises questions about definitions of life.
  • Concerns are raised about the feasibility of creating life without leveraging existing biological mechanisms, suggesting it may be inherently difficult.
  • Some participants reflect on the nature of self-replicating molecules and the implications for understanding life's origins.
  • There is speculation about the conditions necessary for life to emerge, including recreating ancient environments and the role of RNA in early life forms.
  • Discussion includes philosophical questions about chance versus destiny in the emergence of life.
  • Another participant emphasizes that evolution optimizes existing life forms, suggesting that once a viable organism exists, it may hinder the emergence of new forms.

Areas of Agreement / Disagreement

Participants express a range of views on the possibility of creating life from scratch, with no consensus reached. Some agree on the theoretical potential, while others highlight significant practical limitations and differing definitions of life.

Contextual Notes

The discussion reflects limitations in current scientific understanding of cellular assembly and the definitions of life, as well as the historical context of life's origins on Earth. There are unresolved questions regarding the necessary conditions and processes for creating life artificially.

  • #91
Simon Bridge said:
Probably many many times 3.5-4.5 billion years ago... and wait for a long long time ;)

Do we have any reason to believe abiogenesis ever ceased and that is not happening even today?
 
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  • #92
All known species use the same genetic code to translate DNA/RNA to amino acids (sometimes with tiny modifications). If there would have been completely independent evolutions, we would see many different ways.
Life needed a long time to get as competitive as today. I doubt new life would have any chance to survive against current life - it just lacks billions of years of evolution.
 
  • #93
mfb said:
All known species use the same genetic code to translate DNA/RNA to amino acids (sometimes with tiny modifications). If there would have been completely independent evolutions, we would see many different ways.
Life needed a long time to get as competitive as today. I doubt new life would have any chance to survive against current life - it just lacks billions of years of evolution.

I would expect abiohenesis of today would be based on the same principles, guided and limited by the same or similar external factors, so I don't think it would be able to produce anything fundamentally different, on this planet.

Simple self-replicating molecules could have an advantage of being more robust and existing in large quantities. I'm not suggesting it would be possible for flying snake to evolve in today's and the world of tomorrow, but perhaps a new virus, very much similar to those that already exist, yet not quite the same. Of course it would be hard or impossible to tell whether this virus is just a mutation or indeed evolved from something simpler than itself.
 
  • #94
humbleteleskop said:
Do we have any reason to believe abiogenesis ever ceased and that is not happening even today?

It's unlikely abiogenesis is still ongoing because extant organisms are likely to fill any niche where it could occur.
 
  • #95
humbleteleskop said:
Do we have any reason to believe abiogenesis ever ceased and that is not happening even today?

The theory is that if some new kind of life sprang up it would be VERY poor at competing for resources and in fending off the more advanced microbes that would see it as food.

Also, before there was life on Earth, the Earth was a different place. There was no O2 in the atmosphere and so on. The lifeless Earth was a better place for life to develop but now the air is reactive (with O2) and the nutrient-soup is gone.

Life might have arisen many times only to fail until finally life RNA based on four bases happened and then we had RNA based life for a billion years before DNA came along. The first life to survive and multiply "wins" and would prevent anything else from following. It changes the environment so radically while at the same time adapting to the changes, nothing else can follow it
 
  • #96
I agree. However, if something like those self-replicating polymers and fatty acids from Szostak's experiments can occur naturally in large numbers and in an environment sparse or devoid from things that would consume them. Then they could perhaps merge just due to sheer luck and consequently divide like in the experiment.

And then, maybe, just maybe, some of them would turn into something a little bit more robust, something a little bit more likely to merge and divide, and so on... Perhaps at some point external factors would not allow for any further grow in complexity, but it's just a matter of our semantic definition whether we are willing to call those things "alive".
 

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