Components of O Type Blood & Rhesus Factor

[shirrok]

No, there is no way to chemically treat the RBC membranes to remove all the antigens without obliterating the cell itself.

Extended person to person cross-fusion of blood, even if WBCs were kept in the respective hosts, would likely be fatal. At what point, no one can say.

There are about two dozen antigens commonly tested for that can cause hemolytic reactions. The breakdown of person A's RBCs inside person B's body will potentially cause person B to recognize those membrane components as foreign. It will then mount an immune response and kill person A.

For a real life example, look no further than HDN, hemolytic disease of the newborn. It's the entire reason Rh negative women are given rhogam injections--once any fetal cells cross the placenta and are processed by the mom's immune system, her body may make anti-D (antibodies to the most common Rh protein). It will cross the placenta readily and destroy the fetal RBCs.

The same thing would happen between two individuals hooked to one another, only with one of several antibodies, not just anti-D.

Now, if you were to fully suppress their immune system so that they made no antibodies...well, any infection would likely kill them.

 

[Moonbear]

I've just merged several threads together that are all asking essentially the same basic question.

 

[bioquest]

My interest in blood started with being interested in stem cells so and I didn't want to create a new thread

can newts regenerate any part of their head/brain other than jaws and eyes?

 

[NoTime]

This may help with some of your questions.
http://www.sciencenews.org/articles/20080209/bob8.asp

 

[bioquest]

How much is the difference in the amount of clotting enzymes in an old person compared to that of a young person?
What clotting enzymes are different between a young person and an old person?

 

[bioquest]

Is it possible that blood provides "donor" nuclei for neurons in some way?

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=149963

This study demonstrates that although during human development Purkinje neurons are no longer generated after birth, cells within the bone marrow can contribute to these CNS neurons even in adulthood. The underlying mechanism may be caused either by generation de novo of Purkinje neurons from bone marrow-derived cells or by fusion of marrow-derived cells with existing recipient Purkinje neurons. Here we investigated whether bone marrow-derived cells could cross the blood–brain barrier and contribute to neurons in the CNS. Previous studies in mice have shown that bone marrow-derived cells can contribute to neuronal cell types in the CNS, including a class of highly specialized neurons in the brain, the Purkinje neurons (3–5

 

[pico]

O type with a negative RH factor is compatible with all other blood types.

Indeed type O is compatible with other blood types

 

[bioquest]

So you can clone mice dogs cats etc but you can't clone whole-blood from a sample of whole blood?

 

[mgb_phys]

So you can clone mice dogs cats etc but you can't clone whole-blood from a sample of whole blood?

Red blood cells don't have any genetic material - you would have to clone bone marrow cells from any traces of bone marrow in the blood, or from stem cells.
Then grow the marrow cells and have them generate red blood cells.

 

[bioquest]

If you had bone marrow/bone marrow cells could you use it in vitro to generate whole blood? Could you use anything to generate whole blood? (In vitro, outside of the body)

 

[mgb_phys]

It's hard to keep most mammal cells alive in vitro, I think having them function and generate blood cells is pushing current technology.

 

[bioquest]

But hypothetically would they be able to generate whole blood not just red & white blood cells?

 

[bioquest]

So I understand that person-person blood connection would be fatal...

What are the problems it could potentially cause someone/what are the odds it would be fatal, if someone was hooked up to blood but not directly from a second person (ie from a bag) for 5 weeks?

* I realize/remember now that bone marrow doesn't generate whole blood sorry I got that confused

 

[bioquest]

How does White Blood Cell count relate to aging? What sort of impact could/would having a high white blood cell count throughout your entire life have on aging? (Even though they don't have a synthetic white blood cell substitute yet)

Is this a valid theory what do you think about it

. The Autoimmune Theory:

The Autoimmune Theory, proposed by Dr. Roy Walford at UCLA hypothesizes that two types of white blood cells, B and T cells of the immune system weaken with age, and malfunction. B cells lose their vigor in attacking bacteria, viruses, and cancer cells, and the T cells lose their vigor in attacking cells foreign to the body, such as cancer cells and transplant cells. When B and T cells malfunction, they attack normal healthy body cells.

* I understand now that blood transfusions create a lot of problems and have upped my knowledge on them sorry about the previous confusion

 

[Moonbear]

How does White Blood Cell count relate to aging? What sort of impact could/would having a high white blood cell count throughout your entire life have on aging? (Even though they don't have a synthetic white blood cell substitute yet)

Is this a valid theory what do you think about it

. The Autoimmune Theory:

The Autoimmune Theory, proposed by Dr. Roy Walford at UCLA hypothesizes that two types of white blood cells, B and T cells of the immune system weaken with age, and malfunction. B cells lose their vigor in attacking bacteria, viruses, and cancer cells, and the T cells lose their vigor in attacking cells foreign to the body, such as cancer cells and transplant cells. When B and T cells malfunction, they attack normal healthy body cells.

There is no statement of cause or effect there, merely a correlation between aging and weakening of the immune system.

 

[bioquest]

On the subject of aging...

Hypothetically, Is there a way to make using antioxidants more effective than drinking or eating them, ie could you have them be put directly into your bloodstream/have them be used more directly in relation to the DNA than they are when being eaten/drunk? if so, could you expand on that?

 

[bioquest]

This is my only question I think I am done asking questions but I am asking this out of interest

Is Notch one http://www.telomolecular.com/notch1.asp the protein/what it is that caused the stem cells to be stimulated when they connect the blood of the old mouse up to the blood of the young mouse?