COVID COVID-19 Coronavirus Containment Efforts

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Containment efforts for the COVID-19 Coronavirus are facing significant challenges, with experts suggesting that it may no longer be feasible to prevent its global spread. The virus has a mortality rate of approximately 2-3%, which could lead to a substantial increase in deaths if it becomes as widespread as the flu. Current data indicates around 6,000 cases, with low mortality rates in areas with good healthcare. Vaccine development is underway, but it is unlikely to be ready in time for the current outbreak, highlighting the urgency of the situation. As the outbreak evolves, the healthcare system may face considerable strain, underscoring the need for continued monitoring and response efforts.
  • #3,691
Confirmed cases in the US exceeded 1% of its population.

Excluding micronations/territories with a small population: Qatar has 3.5%, Bahrain about 2%, Chile and Kuwait about 1.5%, Oman, Armenia, Panama, Peru and the US a bit more than 1%. Brazil has a bit less than 1% at the moment.
 
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  • #3,692
mfb said:
Confirmed cases in the US exceeded 1% of its population.

Excluding micronations/territories with a small population: Qatar has 3.5%, Bahrain about 2%, Chile and Kuwait about 1.5%, Oman, Armenia, Panama, Peru and the US a bit more than 1%. Brazil has a bit less than 1% at the moment.

One noticeable thing is that the Middle East countries with a large number of cases - Qatar, Bahrain, Kuwait, Oman and Saudi Arabia - have a very low death rate. Not just a low CFR, but a low death rate per population generally. For example:

Saudi Arabia and Italy both have about 243,000 cases now: Italy has had 35,000 deaths, but SA only 2,370.

Canada and Qatar have 109,000 and 105,000 cases respectively, but 8,800 against 150 deaths.

Belgium and Oman have about 63,000 cases each, but 9,800 against 290 deaths.

(As an aside, the global death rate generally is about 60 people per 100,000 per month. If you picked 100,000 of the world's population at random, then about 60 would die in the next month. In other words, 150 deaths from 100,000 people is about the expected death rate given the time COVID-19 has been around.)
 
  • #3,693
With 13% world pop obese. (U.S. 40%) 9% diabetes. 27% hypertension.Thats about 1/2 co morbidities for world population.
 
  • #3,694
morrobay said:
With 13% world pop obese. (U.S. 40%) 9% diabetes. 27% hypertension.Thats about 1/2 co morbidities for world population.

It's worse than 9% for diabeties in the sense that even pre-diabeties is a significant risk factor. It is estimated 1 in 3 people have diabeties or pre-diabeties. I think there is well over 50% of the population with at least one co-morbidity. Over 65 I think a person without a co-morbidity is very much the exception rather than the rule. I do not know if the reason the elderly have a higher death rate is their age or co-morbidities.

Thanks
Bill
 
  • #3,695
The Oxford team developing a adenoviral-based vaccine is planning to test their vaccine by intentionally exposing vaccinated volunteers to the virus:

The team behind the Oxford Covid-19 vaccine hope to begin tests on volunteers who will be intentionally exposed to the virus in a “challenge trial”, a move seen as controversial since there is no proven cure for the illness.

Although challenge trials, in which healthy volunteers are given a pathogen, are routine in vaccine development, taking the approach for Covid-19, where there is no failsafe treatment if a volunteer becomes severely ill, has been questioned.

In human challenge trials volunteers are intentionally exposed in a controlled laboratory setting, meaning the trial can be completed in weeks and requires far fewer people.
https://www.theguardian.com/science...lunteers-lab-controlled-human-challenge-trial

While these challenge trials would quickly be able to give an idea of the efficacy of the vaccine (how well does it protect against infection by the coronavirus), the trial would not provide sufficient data on safety. The safety data would have to come from ongoing phase III trials from the group (which will also provide more data on efficacy in real world situations). According to the Guardian article above, the phase III trials have "recruited 10,000 trial participants in the UK, about 5,000 in Brazil and 2,000 in South Africa, with a second trial in the US aiming to recruit as many as 30,000 participants."
 
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  • #3,696
Ygggdrasil said:
The Oxford team developing a adenoviral-based vaccine is planning to test their vaccine by intentionally exposing vaccinated volunteers to the virus:

I expected that. The Oxford group is very gung ho - I have even heard some refer to them as 'crazy'. It certainly will speed up getting the vaccine out there, but even with volunteers I have concerns about its 'morality'.

This is partly related to the view of some working on vaccines that the Oxford vaccine approach has some inherent problems:
https://www.hospitalhealth.com.au/c...id-19-says-professor-1538816326#axzz6STOe3pbD

At a minimum I would want any volunteer to be aware of the above issues.

I like the suggestion of Professor Petrovsky that, once proven safe, as part of phase 2 trials, using the vaccine to attempt to break up second wave outbreaks. He is preparing plans to do that with his vaccine if the Victoria outbreak gets out of hand and threatens a second wave across all of Australia.

Thanks
Bill
 
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  • #3,697
Several US states register over 0.1% of their population as new cases every week. With 30,000 participants that's over 30 new cases per week if the vaccine does nothing, even if you don't add dedicated tests. Give half of them a placebo, skip the first two weeks, three weeks later you expect 50-100 new cases in the control group and can compare this with the group that got a vaccine. This number might go down in the future if the states get the outbreak under control, of course.

Testing everyone in both groups twice in that time span will increase the statistics a lot (and will give another data point on how many cases the US is missing).
 
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  • #3,698
There is some seemingly good news about immunity.

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
Memory T cells induced by previous pathogens can shape the susceptibility to, and clinical severity of, subsequent infections1. Little is known about the presence of pre-existing memory T cells in humans with the potential to recognize SARS-CoV-2. Here, we first studied T cell responses to structural (nucleocapsid protein, NP) and non-structural (NSP-7 and NSP13 of ORF1) regions of SARS-CoV-2 in COVID-19 convalescents (n=36). In all of them we demonstrated the presence of CD4 and CD8 T cells recognizing multiple regions of the NP protein. We then showed that SARS-recovered patients (n=23) still possesses long-lasting memory T cells reactive to SARS-NP 17 years after the 2003 outbreak, which displayed robust cross-reactivity to SARS-CoV-2 NP.

https://www.nature.com/articles/s41586-020-2550-z

T-cell immunity tests could be more reliable than antibody tests in measuring the spread of coronavirus in the community, according to a new study.

Scientists have found that some patients who had experienced mild symptoms of Covid-19 did not appear to have developed antibodies. However they did show “strong, specific T-cell immunity”, according to the authors of a report in Science Immunology.

“If, as appears the case, measuring T-cell immunity is a more enduring and reliable marker of adaptive immunity in Covid-19 than antibody, it will be valuable to achieve roll-out for health services of commercial T-cell testing kits,” said Rosemary Boyton and Daniel Altmann, professors of immunology at Imperial College London.

https://www.independent.co.uk/news/...-test-t-cell-antibody-community-a9625811.html

Since it has been observed that anti-bodies to sars-ncov-2 can fade quickly, this seems like good news for long term immunity; we may not need anti-bodies. I'm not sure though what it really means, and how it affects vaccines, but it is being suggested it is an important factor.

Moderna’s Phase 1 study also indicated that its vaccine candidate can offer a double defense against the virus. The Telegraph explains that it may be essential for vaccines to provide this type of advanced protection to increase COVID-19 immunity. Not all vaccine candidates will also produce T cells, the report notes. Apparently, at least one major vaccine candidate in China does not lead to T cell production, although The Telegraph doesn’t name the drug.

https://bgr.com/2020/07/15/coronavirus-cure-moderna-vaccine-phase-3-news/
 
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  • #3,699
Stretches of South Texas, especially the Rio Grande Valley and the Coastal Bend, have seen Coronavirus infections spread so quickly in recent weeks as to push local hospitals to their limit. The four-county region that includes Harlingen has just 21 ICU beds still available for a population of about 1.4 million people, according to the latest state data, and ambulance operators have described wait times of up to 10 hours to deliver patients to packed emergency rooms.
https://www.texastribune.org/2020/07/18/texas-coronavirus-hot-spots/
Last Friday, Nueces County Medical Examiner Adel Shaker was shocked to learn that a baby boy, less than 6 months old, had tested positive for COVID-19 and died shortly after.
No mention of a pre-existing condition or co-morbidity.
Two weeks ago, there were just seven positive COVID-19 patients in the Amarillo hospital; by this week, that had more than tripled to 24. Earlier this week, a patient in their 30s died; now, the family of a patient in their 40s is considering withdrawing care.

States of Texas and Florida both reported record high deaths from COVID-19 on Thursday, as states in the south and west of the U.S. continue to bear the brunt of the pandemic.
https://www.newsweek.com/record-coronavirus-deaths-reported-texas-florida-1518617

Florida reported 156 new Coronavirus deaths and nearly 14,000 new cases on July 16, with fatalities from the disease in the state having increased significantly since the end of June and beginning of July, according to the COVID Tracking Project.

On July 1, the seven-day moving average of deaths in the state was 38, whereas on July 16 the figure was 95, according to the Johns Hopkins Coronavirus Resource Center.
 
  • #3,700
The link between blood type and Covid-19 is BS

Native Americans are nearly 100% type O, yet Covid-19 rages across Latin America and threatens to wipe out indigenous groups in the Amazon.

and this study was just published“We showed through a multi-institutional study that there is no reason to believe being a certain ABO blood type will lead to increased disease severity, which we defined as requiring intubation or leading to death,” said senior study author Anahita Dua, HMS assistant professor of surgery at Mass General.

“This evidence should help put to rest previous reports of a possible association between blood type A and a higher risk for COVID-19 infection and mortality,” Dua said.

https://hms.harvard.edu/news/covid-blood-type
 
  • #3,701
Astronuc said:
I believe 'probable' cases are treated separately, but it's not clear how uniform and consistent the reporting is across 50 states and the 3000+ counties.
From - https://news.yahoo.com/texas-erases-covid-cases-fans-091650711.html
“The case data on our website reflect confirmed cases, and cases identified by antigen testing are considered probable cases under the national case definition,” said Chris Van Deusen, a spokesman for the Texas Department of State Health Services.

Under that definition, the CDC only considers cases “confirmed” if they are diagnosed using a molecular, often called PCR, test. Cases that are detected using antigen tests are classified as “probable.” If someone is diagnosed with an antigen test, Texas will not count their case among the state total.

The removed cases were from Bexar County, which includes San Antonio. The city’s mayor said Thursday that San Antonio was one of three cities in Texas that tracks antigen tests—and that the tests help local health officials “see the full picture” of COVID-19 in the area.

Article with map of states with and without mandatory wearing of face (nose and mouth) covering/masking.
https://finance.yahoo.com/news/coro...-that-america-needs-to-regroup-164519833.html

Coronavirus Testing Basics
https://www.fda.gov/consumers/consumer-updates/coronavirus-testing-basics

https://www.centerforhealthsecurity.org/resources/COVID-19/COVID-19-fact-sheets/200410-RT-PCR.pdf
 
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  • #3,702
Something published today: https://www.thelancet.com/lancet/article/s0140-6736(20)31604-4
Interpretation: ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support large-scale evaluation of this candidate vaccine in an ongoing phase 3 programme
 
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  • #3,703
500 people, 2-3 months since they got the vaccine, antibodies look good, no one got seriously ill but mild to moderate side effects 2-3 days after vaccination are pretty common (figure 1 B). These side effects can make it more difficult to distribute the vaccine - most people will know someone who had them.
 
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  • #3,704
bhobba said:
Sure - analyse it through that paradigm if you like. Ultimately in a democracy the people decide.
Yes, and that's what has me upset. In most developed countries in the world, "we" have chosen to allow thousands to hundreds of thousands of deaths because of concern over a vague/undefined privacy risk. I find that despicable.
For example people are now saying, including even me, fine and arrest those just exercising their privacy to protect the rest of us. An example is those refusing to take Covid tests. That is their legal right, but the push now is, not to take away that privacy, but to fine and force them into lockdown in a hotel at their own expense. Actually the government through biosecurity legislation can force them to take the test, but do not want to go that far - yet.
Ironically, many if not most of the legal mechanisms are already in place, but are only used on a case by case basis, not wholesale. We have had examples of forced quarantines, subpoenas for contact tracing, and mandatory affirmative proof of infection status.
atyy said:
It's not clear the apps work without traditional contact tracing and quarantine of confirmed cases and close contacts.
[snip]
(which one may need to anyway, even if there is an app).
I don't understand -- they are at least logically equivalent, so what would be the difference that would require traditional contact tracing? What would traditional contact tracing do that the app couldn't?

Also, doesn't South Korea provide clear-cut evidence that this method works?
If traditional contact tracing is in place, then it may be possible that the app need not be compulsory. Thus for example, it appears that the contact tracing for some of the early cases in the US was very well done.
From what I've seen, the lag time of traditional contact tracing makes it basically pointless for COVID. One of the early cases in PA was quickly identified and traced, and all the contact tracing accomplished was following the tree of infection after it had already spread:
https://www.inquirer.com/health/cor...-international-travel-infection-20200428.html
Another approach is to scale that up considerably
The scale problem seems intractable to me. A few months ago people had talked about returning to contact tracing and scaling-up to hundreds of thousands of tracers in the US, but it hasn't happened.
 
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  • #3,705
russ_watters said:
Also, doesn't South Korea provide clear-cut evidence that this method works?
It provides evidence that this method works in South Korea and with years of preparations.

The reaction by the Japanese government is essentially non-existent (school closure, okay, and non-mandatory suggestions), but Japan got the outbreak much better under control than the US. What does that tell us? Certainly not "what works in a completely different culture must work here, too".

I have mentioned that before (e.g. in the context of Sweden): Comparisons work better the more similar the countries are.
 
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  • #3,706
The Department of Homeland Security (DHS) Science and Technology Directorate (S&T) has established the Probabilistic Analysis for National Threats Hazards and Risks (PANTHR) program to strengthen customer engagement within the homeland security enterprise by aligning chemical, biological, radiological, and nuclear (CBRN) hazard awareness and characterization activities to provide timely, accurate, and defensible decision support tools and knowledge to stakeholders. So naturally, they are studying the SARS-CoV-2 virus.

ANTHR is working on characterizing the virus responsible for the COVID-19 pandemic. The work being done will provide insight regarding how long the virus can survive on surfaces, the potential for those contaminated surfaces to infect additional individuals, and the ability of various disinfection technologies to clean these surfaces to prevent further infection/transmission.

https://www.dhs.gov/science-and-technology/panthr

DHS staff have developed two calculators to predict the viability of the virus in air and on surfaces.

Estimated Airborne Decay of SARS-CoV-2 (virus that causes COVID-19)
under a range of temperatures, relative humidity, and UV index
https://www.dhs.gov/science-and-technology/sars-airborne-calculator

Estimated Surface Decay of SARS-CoV-2 (virus that causes COVID-19)
on surfaces under a range of temperatures and relative humidity
https://www.dhs.gov/science-and-technology/sars-calculator

Airborne SARS-CoV-2 Is Rapidly Inactivated by Simulated Sunlight
https://academic.oup.com/jid/article/doi/10.1093/infdis/jiaa334/5856149
 
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  • #3,707
mfb said:
It provides evidence that this method works in South Korea and with years of preparations.
I'm not sure the "years of preparations" has been that big of a contributing factor. The needed legal mechanisms and the apps themselves are really simple.
The reaction by the Japanese government is essentially non-existent (school closure, okay, and non-mandatory suggestions), but Japan got the outbreak much better under control than the US. What does that tell us? Certainly not "what works in a completely different culture must work here, too".

I have mentioned that before (e.g. in the context of Sweden): Comparisons work better the more similar the countries are.
You're trying to play opposite sides of a coin here, but you're making the mirror of mistake you're accusing me of: "what works in a completely different culture won't work here because of the culture." Reality is more nuanced than the simplistic categorizations you are making here -- and for Sweden. It's really important to try to identify what factors matter about countries that make them similar or different, and not choose arbitrary or irrelevant ones, or ignore relevant ones.

If Japan and South Korea succeeded more because they have a strong culture of compliance (certainly likely a contributing factor), it makes the need for compulsory measures is greater in countries with a higher propensity toward freedom/individualism, because there's greater "room" for such measures to make a difference.

E.G., the difference between Japan and South Korea's deaths is 25%. If, as you say, they are highly comparable societies, then that difference may be explainable by the difference in approach. So one would expect the worst-case impact of such measures here to be a 25% reduction in deaths in other societies. In the US, that would be 38,000 lives saved and counting.

But what really blows my mind here is that even in the face of many thousands of deaths, people aren't even interested in trying.
 
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  • #3,708
Here is a map of the proportion of people wearing masks, based on interviews, as described in this NY Times article.
Screen Shot 2020-07-21 at 8.10.37 PM.png


Here is a map of average daily corona virus cases in the last 7 days, from the NY Times, here.
Screen Shot 2020-07-21 at 8.14.25 PM.png
 
  • #3,709
russ_watters said:
I'm not sure the "years of preparations" has been that big of a contributing factor.
I'm not sure either. That means South Korea's success doesn't imply that this would have to work elsewhere. I haven't seen a convincing argument that this infrastructure - legal and technical - could be set up in a short time. No country managed to do so.
russ_watters said:
You're trying to play opposite sides of a coin here, but you're making the mirror of mistake you're accusing me of: "what works in a completely different culture won't work here because of the culture."
I don't say that. I said that using South Korea as evidence that this must be very helpful is problematic. Maybe it would be very helpful. I don't know - and I don't claim I would.
russ_watters said:
So one would expect the worst-case impact of such measures here to be a 25% reduction in deaths in other societies.
Sorry, but that approach is absurd in every aspect.
 
  • #3,710
russ_watters said:
I don't understand -- they are at least logically equivalent, so what would be the difference that would require traditional contact tracing? What would traditional contact tracing do that the app couldn't?

One problem seems to be that distance is hard to infer using bluetooth. If we quarantine a lot of people who are not close contacts, people will think the system is crying wolf.
Inferring distance from Bluetooth signal strength: a deep dive
Why Bluetooth apps are bad at discovering new cases of COVID-19

My understanding is that in Singapore, where the spread seems to be reasonably well managed, the bluetooth app is not yet compulsory, and traditional contact tracing has been beefed up a lot. We'll probably have to wait 3 to 6 months before they release a paper on how much the app is helping with contact tracing.

I should say that the bluetooth tracing is not the only tech tool in Singapore. Everyone here has an identity card, and one's identity card number must be logged when one enters public places like malls, supermarkets and restaurants. For convenience, the logging can be done by another functionality packaged with the bluetooth app, but they are separate functions. Use of the app is not compulsory. The entry registration is compulsory, and can be done by methods other than using the app.

Here is an example of the public messaging on the bluetooth tracing (TraceTogether) and entry registration systems (SafeEntry): https://nusmedicine.nus.edu.sg/images/resources/newsinfo/Jul2020/newsinfomain_COVIDChronicles75_200718.jpg
 
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  • #3,711
russ_watters said:
Also, doesn't South Korea provide clear-cut evidence that this method works?

I think South Korea also has a lot of traditional contact tracing. If I understand you correctly, you think that the US is doing so poorly at traditional contact tracing, that maybe the bluetooth tracing app will help (without the traditional contact tracing). Maybe you are right, but I think South Korea has both, so it isn't a case study on whether the app would be effective without the traditional methods.
 
  • #3,712
Things are getting bad in Victoria Australia.
https://www.couriermail.com.au/news/lawfirm-outbreak-prompts-probe-decision-on-restrictions-looms/news-story/b452755511bfb4c7a33ec5cebae44783?utm_source=CourierMail&utm_medium=Email&utm_campaign=Editorial&utm_content=CM_NEWS-ALERT_CUR_01&net_sub_id=311202432&type=curated&position=1&overallPos=1

It's very sad 9 out of 10 people do not immediately isolate while waiting for Covid test results or are found to have it. Surely they realize how dangerous that is. In a practical sense all that will happen is stronger measures will be taken such as wearing bracelets like they do with house detention. This will tie up police time to implement who could instead be helping wth tracing etc.

Thanks
Bill
 
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  • #3,713
mfb said:
Testing everyone in both groups twice in that time span will increase the statistics a lot (and will give another data point on how many cases the US is missing).

I think the initial data suggests a number of vaccines actually work in the sense of reducing the number of people that get Covid. What we do not know is long term effects which makes this whole thing tricky. Even the idea of using stage two trials to try and break up hot spots with small numbers vaccinated has me a bit worried long term. This is going to be a very difficult decision to make morally. Things here in Aus are breaking down to some extent with more people not adhering to rules. If they only show a bit more sense then we can wait longer to deploy the vaccine and get better safety data.

Thanks
Bill
 
  • #3,714
atyy said:
Maybe you are right, but I think South Korea has both, so it isn't a case study on whether the app would be effective without the traditional methods.

In Aus it is thought the app is not doing much good over and above normal tracing methods. There seem to be a number of reasons, one of which is many phones go into an idle mode while not being used and the app is then not working. Also it does not help with cases picked up from surfaces or fine droplets that remain longer in the air and do not fall to the ground quickly.

Thanks
Bill
 
  • #3,715
atyy said:
One problem seems to be that distance is hard to infer using bluetooth.
I'm not referring to the Google/Apple platform. Yes, it's fundamentally flawed and largely useless. I'm referring to a properly made system that would use GPS; My understanding is South Korea and several other countries use GPS. The irony is that Apple and Google already collect GPS location data, they're just choosing not to use it.

India is also using GPS in a compulsory app, which may explain why a country you'd expect COVID to blast through is instead seeing a slow burn.
atyy said:
I think South Korea also has a lot of traditional contact tracing. If I understand you correctly, you think that the US is doing so poorly at traditional contact tracing, that maybe the bluetooth tracing app will help (without the traditional contact tracing).
GPS based, but yes, that is my position.
Maybe you are right, but I think South Korea has both, so it isn't a case study on whether the app would be effective without the traditional methods.
Well, it's all layers, right? It's social distancing + masks + quarantines + contact tracing + etc...

It's all hands on deck for our Covid containment efforts, trying everything that might help regardless of firm evidence that it will help -- except that. No, we can't even consider that.
 
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  • #3,716
russ_watters said:
"we" have chosen to allow thousands to hundreds of thousands of deaths because of concern over a vague/undefined privacy risk.

Let me try and clarify it, then:

(1) The guiding and limiting principles on what actions the government may take in emergencies are least as vague and undefined. If it is "any action is permissible if it saves just one life" that takes us to a place where the government can tell us what to eat (obesity is at least as serious an issue as Covid) and who to marry (wouldn't want genetic problems in the offspring, now would we?)

(2) It would likely be a permanent state of affairs. If you divide the country in two pieces: NY, NJ, MA and CT in one, and the other 46 in the other, the Covid fatality rate in the "other 46" is about the same as a really bad flu season. If it's worth imposing mandatory contact tracking to the Other 46 now, why would we not impose it every year for influenza?

If you're still not convinced, we could probably eliminate STDs. All we need to do is create a national database of everybody and their sexual partners. Think of the suffering we would eliminate!

(3) I for one, and probably others, are skeptical of the competency of governments to act on this information. Ultimately, the premise of contact tracing is that this is an information problem. More information and the problem will be solved. But let's look at the situation in the Four States listed above and nursing homes. The vulnerability of the elderly to Covid was well-established. The fact that individuals had Covid was known. And yet these people were deliberately moved into nursing homes. Around half the deaths in the Four States were in nursing homes.

(4) Keeping a list of people who were at "defund the police" rallies and handing that list to the police - purely for health reasons, you know - makes people uneasy. And while one might say "governments/police are too noble to act on this information", and I might even agree with them, the people who are protesting would not.

I would argue that if you want to bring people around to your way of thinking you should address these points. I would especially focus on the limiting principle.
 
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  • #3,717
russ_watters said:
The irony is that Apple and Google already collect GPS location data, they're just choosing not to use it

That's due to privacy concern. It's the old privacy vs public safety debate. I come down on the side of public safety and would use it - evidently Taiwan does and it is still doing well. But we live in a democracy so it's not my choice to make.

We can control it with strict rules and public cooperation, but as has been seen in Australia that now looks like it may be breaking down as people tire of it. The vaccine may be the only hope.

Thanks
Bill
 
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  • #3,718
I just read a headline that the US government has placed an order for 300 M doses of a SARS-CoV-2 vaccine. The WSJ reports a 100 M dose order (should it be cleared by regulators).
https://www.wsj.com/articles/pfizer...vaccine-order-from-u-s-government-11595418221

COVID-19 Vaccine Efforts at Pfizer
https://www.pfizer.com/science/coronavirus/vaccine

Some results - https://www.pfizer.com/news/press-r...iontech-announce-early-positive-update-german

Meanwhile, AstraZenaca's vaccine is showing promise.
https://www.astrazeneca.com/media-c...-in-all-participants-in-phase-i-ii-trial.html

I heard a claim on the news last night that the AZ vaccine might be ready by September. Seems like hype at the moment.
 
  • #3,719
russ_watters said:
It's all hands on deck for our Covid containment efforts, trying everything that might help regardless of firm evidence that it will help -- except that. No, we can't even consider that.

Well, the thing is we know that the traditional contact tracing does work, and we are not sure whether a GPS app works without the traditional contact tracing. In all cases, it is essential for the public to trust the government. Trust seems already to be at such low levels in the US, maybe it's better to spend it on the traditional methods (which we know works), rather than squandering what little is left of the trust on an untested method that many are suspicious of (and which may not work without the traditional methods).

But incidentally, can GPS alone really contact tracing? Does it work well enough indoors to tell whether people are less than 2 meters apart?
https://www.gps.gov/systems/gps/performance/accuracy/
" For example, GPS-enabled smartphones are typically accurate to within a 4.9 m (16 ft.) radius under open sky (view source at ION.org). However, their accuracy worsens near buildings, bridges, and trees. "
 
  • #3,720
Vanadium 50 said:
Let me try and clarify it, then:

(1) The guiding and limiting principles on what actions the government may take in emergencies are least as vague and undefined. If it is "any action is permissible if it saves just one life" that takes us to a place where the government can tell us what to eat (obesity is at least as serious an issue as Covid) and who to marry (wouldn't want genetic problems in the offspring, now would we?)...

(2) It would likely be a permanent state of affairs. If you divide the country in two pieces: NY, NJ, MA and CT in one, and the other 46 in the other, the Covid fatality rate in the "other 46" is about the same as a really bad flu season. If it's worth imposing mandatory contact tracking to the Other 46 now, why would we not impose it every year for influenza?...

(3) I for one, and probably others, are skeptical of the competency of governments to act on this information.

(4) ...
(1) Yes, it's a slippery slope, and we're always on it. Governments make such decisions every day - it's a core issue of governance. Philadelphia has a soda tax(!), and it isn't small. This is something decided case-by-case, with oversight and framing based on our governments' structures. In this case, "we" have decided that it's a health emergency and as such massive restrictions on freedom and massive costs are permissible to save lives. But zero cost in privacy is worth it to save any number of lives, money or freedom. If you're worried about that slope, I don't see why: none of us have ever seen anything like the current government response in our lifetimes. Though we do see several disaster declarations a year for floods/hurricanes. There's usually FEMA-associated conspiracy theories about where those powers could lead, but they've been pretty quiet lately.

(2) I don't see why it should be considered likely to be permanent. Many(most?) countries have passed COVID-specific response laws. Even countries like South Korea that had mechanisms in place for this required explicit authorization to apply it to COVID. Your logic in comparing it to flu(or STDs) doesn't apply because:
a) The decision has been made that this is worse than the flu, and more on par with a hurricane. If we decide it isn't worse than the flu, then no emergency response is warranted at all. This is the same as your #1: it's never happened in our lifetimes, so I see no reason to expect it to be permanent/continuous.
b) Your logic of comparing it to flu doesn't work because the current state of COVID is after/with a shutdown. If we weren't already taking emergency measures, COVID would be much worse in health impact. It's already much worse in financial and freedom impact.

(3) Whether governments or individuals, clearly competence has been a problem in the pandemic response. But this problem is independent of the issue of improving contact tracing. Improving contact tracing can't make it worse, it can only improve it. The guy who tries to go shopping without a mask might still go to the grocery store even if their app buzzes and tells them there's 5 infected people clustered right in front of him at the front door. But would you? I wouldn't. And I'd wager there's not an insignificant number of outspoken people who talk tough on facebook, but would cave if the information was shoved in their face/pocket. [edit] I'll add that I favor coercion be included in this apps, but we haven't even gotten to that yet...

(4) I'm not following/understanding this example at all.
I would argue that if you want to bring people around to your way of thinking you should address these points. I would especially focus on the limiting principle.
The limiting principle is that a health emergency like this hasn't happened in our lifetimes before, so there is no reason to expect it to happen again, much less be applied continuously. That's the typical fallacy of slippery slopes: they are an effect without a cause or historical precedent/evidence.

By the way, this is all good discussion, but your issue is more with treating COVID as an emergency than it is with the specific emergency response measure. Since COVID has already been declared an emergency, that's not what is standing in the way of digital contact tracing. What's standing in the way is privacy concerns, and specifically, Apple and Google decided/declared that they'd be creating an ineffective digital contact tracing system in order to prioritize privacy over effectiveness.
 
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