Different folding options for a protein?

  • Thread starter icakeov
  • Start date
365
23
Hello, I was wondering whether one same protein can assume different foldings that can do different functions in the organism? (each folding still having the usual active/inactive state)

And if the is a specific example for this?

Many thanks for any thoughts!
 
Have you been to https://fold.it yet? You may find that folding proteins is fun and challenging.
 

BillTre

Science Advisor
Gold Member
2018 Award
1,048
1,562
assume different foldings that can do different functions in the organism? (each folding still having the usual active/inactive state)
I think, generally, motor proteins fulfill your conditions.
As they move back and forth (different conformations), they will be doing functions (moving things or different steps in the overall movement cycle), and to some degree maintain their active sites (binding sites?).
An example is the actin-myosin contraction cycle.

Another similar example could be proteins involved in membrane fusion during vesicle release in response to calcium ions entering a nerve terminal.
Go to SNARE protein and pore formation in this link.
This is a complex system with many parts binding other parts at different times during the process (which has a lot of other steps in addition).

Going the opposite way (from the membrane's point of view), clathrin is involved in vesicles pinching off from a membrane sheet. These molecules are flexible (implying a continuum of shapes) and bind to themselves and other proteins in order to form vesicles.

Another possible group could be enzymes moving along a linear molecule like DNA or RNA. I am guessing these are changing conformation as they cycle along, but I don't really know for sure.
 
365
23
Super helpful responses! Thank you so much!
 

Want to reply to this thread?

"Different folding options for a protein?" You must log in or register to reply here.

Physics Forums Values

We Value Quality
• Topics based on mainstream science
• Proper English grammar and spelling
We Value Civility
• Positive and compassionate attitudes
• Patience while debating
We Value Productivity
• Disciplined to remain on-topic
• Recognition of own weaknesses
• Solo and co-op problem solving

Hot Threads

Top