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- Asking questions about protein structure determination

Hi,

I tend to write down questions/thoughts that come to me as I read articles that are interestsing. I'm reading the intro to solution state NMR in a biophysics textbook.

Any there any purely theoretical approaches to determine protein structure / dynamics ?

The 1 dimensional digital code of DNA is easily obtained. And, wouldn’t it be more efficient to develop a sophisticated computer software that runs on pure computational power to determine the 3d structure, when we input the 1 dimensional data? Would this immense computational power? Does P = NP?

Leonard Susskind said calculations involving the folding of a hypothetical molecule of a hundred atoms results in an energy diagram with over 10^100 discrete “valleys” representing locally stable conformations. Still, with constraints given by the amino acids and their sequence, we would be able to lower that number significantly. Given proteins obey the laws of thermodynamics, will the task of determining protein structure be no longer a difficult task one day?

I tend to write down questions/thoughts that come to me as I read articles that are interestsing. I'm reading the intro to solution state NMR in a biophysics textbook.

Any there any purely theoretical approaches to determine protein structure / dynamics ?

The 1 dimensional digital code of DNA is easily obtained. And, wouldn’t it be more efficient to develop a sophisticated computer software that runs on pure computational power to determine the 3d structure, when we input the 1 dimensional data? Would this immense computational power? Does P = NP?

Leonard Susskind said calculations involving the folding of a hypothetical molecule of a hundred atoms results in an energy diagram with over 10^100 discrete “valleys” representing locally stable conformations. Still, with constraints given by the amino acids and their sequence, we would be able to lower that number significantly. Given proteins obey the laws of thermodynamics, will the task of determining protein structure be no longer a difficult task one day?