Here is the second installment of my friend's response.
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Where complex structures like a nose and mouth are concerned, it must be appreciated that they did not arise as a single mutational event, but developed as stepwise elaborations of primordial structures. In multicellular invertebrates that are either sessile or that do not benefit from movement in a straight line (e.g. sea cucumber, slime mold) there is no selective advantage to development of a midline around which structures are placed symmetrically. However, in multicellular vertebrates for whom movement is a straight line is advantageous for targeting food sources, escaping predators, etc., development around a midline has a selective advantage. Symmetrical development around this midline helps maintain this selective advantage (fins on either side of the fish vertebral column, legs on either side of the early amphibians), and this arrangement thus dominates the anatomy of multicellular vertebrates. The nose is not a single structure but a complex one that connects both to the respiratory system and the brain. It is situated around the midline, with parts placed symmetrically on either side of the midline. The same holds for the mouth, which is just a part of the digestive system. While it’s theoretically possible to find a mouth at, say, the top of the forehead in the midline, evolution of the digestive system occurred in a coordinated fashion with the central nervous system. For the mouth to be at the very top of the head, the esophagus would then have to travel through the brain without disrupting brain function, which depends on communication between neurons on either side of the midline, and which was also evolving with the digestive system. Given the arrangement of these structures in primordial species, it is highly unlikely that any single genetic event could effect such a dramatic rearrangement. Moreover, were that to happen, it is prohibitively unlikely that the new arrangement would confer a selective advantage.
The notion that complex structures arise as stepwise changes in corresponding systems found in ancestral species also holds for networks like the circulatory system. Circulation arose to allow cells deep inside solid organs receive needed oxygen, and once the system developed, it is not feasible to imagine new organ systems arising that would obtain oxygen by some other method. Note that in insects, which are invertebrates whose evolutionary tree goes back to ancestral invertebrates that did not have a circulatory system, such a system does not exist, and cells receive oxygen through conduits that connect from the surface of the body. The insect system is not too different from that of the invertebrate sea cucumber. It’s not surprising that the insect system is not well adapted to vertebrate organisms with very large organs that may be billions of cells thick. So, the insect system is built on the tubule structure also found in the sea cucumber, while the arterial/venous system is descended from the oxygenation system of early vertebrates.
The underlying motive force for skepticism about complex structures evolving rather that being designed by an intelligence stems, in my view, from a lack of appreciation of the amount of time evolution has been taking place. Most people cannot really get a handle on a time frame of 40 million centuries, which is a reasonable estimate of the time since life first appeared. A lot of genetic experiments that failed can take place over that expanse of time. "