The eigenfunction expansion method in solving partial differential equations (PDEs) relies on self-adjoint differential operators, where eigenfunctions form an orthonormal basis for the solution space. This method is particularly effective under homogeneous boundary conditions, as it ensures orthogonality among eigenfunctions, which is crucial for constructing solutions using Fourier series. The discussion highlights that non-homogeneous boundary conditions prevent the formation of a vector space of solutions, as the sum of two solutions may not satisfy the original equation. The second derivative operator is identified as a self-adjoint operator under specific conditions, emphasizing the importance of boundary conditions in determining the applicability of this method. Overall, the eigenfunction expansion method is a powerful tool for solving PDEs when the appropriate conditions are met.