If you don't go with the energy approach, you'll want to find the angular acceleration of the pulley system.
You can use these equations:
[tex]
\begin{align}<br />
\vec{\tau} &= \vec{r} \times \vec{F} \\<br />
\vec{\tau}_{net} &= I\vec{\alpha}_{net}<br />
\end{align}[/tex]
In these equations, [itex]\vec{\tau}[/itex] is torque, I is moment of inertia, [itex]\vec{\alpha}[/itex] is angular acceleration, and r is the distance vector from the axis of rotation to the force F.
These are the rotational analogues to force and Newton's second law. You can use Eq. (2) on the pulley system to find the net angular acceleration, which will give the system's acceleration. To find the linear acceleration of the block, [itex]\vec{a} = r\vec{\alpha}[/itex].