Finding the Right Adhesive for Affixing Myocardial Tissue to Polyethylene Tubing

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Discussion Overview

The discussion revolves around finding an appropriate adhesive for affixing myocardial tissue to polyethylene tubing. Participants explore various adhesive options, considering their effectiveness and implications for tissue properties.

Discussion Character

  • Exploratory, Technical explanation, Debate/contested

Main Points Raised

  • Some participants suggest cyanoacrylate adhesives, including medical-grade options like Ethicon's Dermabond, as viable choices for bonding tissue.
  • Others mention the availability of two-part cyanoacrylate adhesives that may provide instant bonding but express uncertainty about their effectiveness on polyethylene tubing.
  • A participant humorously proposes duct tape but later references a product related to liquid bandages, questioning its suitability.
  • Concerns are raised about the potential impact of adhesives on the mechanical properties of the myocardial tissue at the attachment point, with some suggesting that it may not propagate through the tissue.
  • One participant notes the difficulty of adhering to polyethylene tubing, suggesting an alternative approach of using glass to connect the sample.
  • A participant indicates that their lab plans to test the cyanoacrylate options and will share results, noting similarities between hospital liquid bandages and super glue.

Areas of Agreement / Disagreement

Participants express a range of opinions on adhesive options, with no consensus on the best choice or the implications of using these adhesives on the tissue and tubing.

Contextual Notes

There are uncertainties regarding the mechanical properties of the tissue after adhesive application and the effectiveness of different adhesives on polyethylene tubing, which is noted to be difficult to bond.

tandoorichicken
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Ahem... no pun intended. :-p

Actually, I need an adhesive to affix a snippet of myocardial tissue to some polyethylene tubing. Any ideas?
 
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Have you tried cyanoacrylate (sometimes branded as super glue)?
Some are meant for "medical" applications and bind to tissue very readily.

e.g., Ethicon's Dermabond
 
I'd also first consider the cyanoacrylates. In addition to the one-part adhesives that require some drying time, they're also available as two-part adhesives, so you can get nearly instant bonding as soon as you mix the two components. It'll work for tissue, I'm not sure if it will work as well on the PE tubing. That stuff is notoriously "slippery."
 
I'll run the dermabond/cyanoacrylate idea by my superiors... will it change the mechanical properties of the tissue?
 
Yes - at the point of attachment, but if you meant will it propagate thru the tissue, I have no idea. Since it's used on humans where progagating new properties into surrounding tissue is a no-no, I'm guessing it will not.

You need to hit the company literature...
 
HOw about that stuff they sell for treating cuts? Some call it liquid bandage, or "Newskin".
 
I'm with MoonBear on the PE tubing.
Nothing I know of really sticks to it.
Could be you would be better off plugging a short bit of glass into the tubing and fixing the sample to that.
 
Well, my lab is going to order some and find out. Best way to find out I suppose. It should work, judging from the fact that super glue is also a cyanoacrylate glue. I found out that the liquid skins used in hospitals are just molecularly heavier versions of super glue. I'll let you all in on the results once we try it out.
 

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