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Biology and Medical
Freezing temperature of vaccines
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[QUOTE="Ygggdrasil, post: 6447013, member: 124113"] The issue is not the freezing point of the solution, but the stability of the RNA molecules. mRNA molecules are designed to be short lived and are therefore very susceptible to degradation (the sugar-phosphate backbone is capable of binding to and activating common metal ions, like Mg[sup]++[/sup], to catalyze the degradation of the RNA molecule). It is very common in laboratories to store RNA at -70°C (e.g. see the "How to Store RNA" section of the website below): [URL]https://www.thermofisher.com/us/en/home/references/ambion-tech-support/nuclease-enzymes/general-articles/working-with-rna.html[/URL] [/QUOTE]
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Freezing temperature of vaccines
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