More properly, which E8 representation does he use?
From what I gather, it's the 248 representation, which is both the fundamental one and the adjoint one.
Fundamental -- every other irreducible representation can be derived from product representations. If Xi is the rep's vector space, the product representations are Xi*Xj*Xk...
Adjoint -- the rep's vector space is the generators of the algebra. Gauge fields must be in the adjoint rep of their gauge algebra.
So gauge fields must be in the E8 248 rep.
The next larger E8 rep has size 3875, which is even worse.
For the 3D angular-momentum algebra, a.k.a. A1, B1, SU(2), SO(3), etc.:
Fundamental: spinor (spin 1/2, dimension 2)
Adjoint: vector (spin 1, dimension 3)
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It's rather obvious that no experimentally-accessible particles have unbroken E8 gauge symmetry, so it must be broken in some way. But there are lots of ways to break E8:
D8 = SO(16)
A7*A1 = SU(8)*SU(2)
A5*A2*A1 = SU(6)*SU(3)*SU(2)
A4*A4 = SU(5)*SU(5)
D4*A3 = SO(10)*SU(4)
E6*A2 = E6*SU(3)
E7*A1 = E7*SU(2)
A8 = SU(9)
D7*U(1) = SO(14)*U(1)
A6*A1*U(1) = SU(7)*SU(2)*U(1)
A4*A2*A1*U(1) = SU(5)*SU(3)*SU(2)*U(1)
A4*A3*U(1) = SU(5)*SU(4)*U(1)
D5*A2*U(1) = SO(10)*SU(3)*U(1)
E6*A1*U(1) = E6*SU(2)*U(1)
A7*U(1) = SU(8)*U(1)
F4*G2
Some of these subgroups contain not only the Standard-Model symmetry, SU(3)*SU(2)*U(1), but also such much-discussed supersets of it as SU(5), SO(10), and E6.
The Pati-Salam model, mentioned in the OP, has symmetry SU(4)*SU(2)*SU(2) or SO(6)*SO(4)
It's a subset of SO(10), and thus, E6 and E8.