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Homework Help: Genetics Chromosomal Inversion problem

  1. Nov 18, 2017 #1
    1. The problem statement, all variables and given/known data
    Rewrite following sequence as double stranded molecule, with an inversion of the sequence between nucleotide 4 and 12.

    5'-TCTCGCATGGTAGGT-3'

    2. Relevant equations
    none.

    3. The attempt at a solution

    I've read in the textbook that you take the section and rotate it 180 degrees, then reinsert it. However I think that I'm not understanding this properly because when I do this, I get a 5' end that needs to be rejoined with another 5' end, and likewise with the 3' end:

    Original: 5'-TCTCGCATGGTAGGT-3'
    Taking out sequence which needs to be inverted: 5'-GCATGGT-3'
    Invert: 3'-TGGTACG-5'
    Inverted sequence:5'-TCTC-3' (3'-TGGTACG-5') 5'-AGGT-3' ...so I don't see how I can rejoin the inverted segment.

    I feel like I'm missing something obvious, if someone could help me out with this it would be great.
     
  2. jcsd
  3. Nov 21, 2017 #2

    Ygggdrasil

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    Science Advisor
    2017 Award

    Remember that DNA is double stranded. When you rotate the DNA 180° will the same strand of DNA be on top?
     
  4. Nov 21, 2017 #3
    Thanks!
     
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