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Biology and Medical
Germline mutations are more harmful than mutations in somatic cells?
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[QUOTE="Drakkith, post: 6489042, member: 272035"] Yes, it's possible for the mutation to have an effect. For example, if the mutation changes the base pairs in such a way as to form a start codon, then the cell can accidentally translate and produce proteins from the wrong portion of the DNA molecule. This can have any number of effects on the cell, from barely noticeable all the way up to cell death. It's possible. It depends on the exact mutation and its location. Some mutations are simply neutral. Some are negative, and some are positive depending on the interaction of the organism with its environment. Generally, yes, because, as you said, a mutation in the germline would be passed on to every cell in the offspring. So a mutation that degrades ATP production would harm only a single somatic cell, whereas in germline cells it can cause systemic, chronic, and potentially lethal birth defects in offspring. [/QUOTE]
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Germline mutations are more harmful than mutations in somatic cells?
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