Mapes
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I agree with Andy. You surely believe that at least some of the journal's readers will follow and understand your arguments, be familiar with the topics even if somewhat outside their specialty, and be interested in the conclusions. These are your potential referees. They are in a good position to judge your points. Remember this when they come back with (possibly negative) comments. Since you have written a book in the field, I'm sure you've thought carefully about how to present research conclusions clearly and to the widest possible audience.
Also, you've mentioned that your paper is a review/consolidation of existing studies that argues for a new unified theory. I think your idea that referees can or will question the validity of the original data is way off base. The published studies have been through peer review and have a high degree of believability. Your manuscript has not (yet). The referees will be focusing on your contributions.
Also, you've mentioned that your paper is a review/consolidation of existing studies that argues for a new unified theory. I think your idea that referees can or will question the validity of the original data is way off base. The published studies have been through peer review and have a high degree of believability. Your manuscript has not (yet). The referees will be focusing on your contributions.