Although I do understand that R&D, testing, insurance, legal costs, etc serve to legitimately drive the cost of medications much higher than might seem reasonable, I was shocked by this one! I have psoriasis and use a number of topical meds to keep it in check. I was aware that these meds were expensive, but I didn't realize that the insurance was paying over 75% of the cost. That is, I had never noticed the retail price for what I'm using. One of these is a cream that is about twice the price of the rest by weight. It is a 0.005% calcipotriol cream that comes in a tube that holds 120 grams of it [about the size of a large tube of toothpaste], so we are talking about 6 mg of the active ingredient. Retail price: $466.00. So this is about $78 per mg, and rest come out at about $40 per mg of active ingredient. If this were some kind of miracle drug that made a severed arm grow back then I might expect a price like this, but I have a hard time understanding how this price is justified. I think this is pretty common stuff used by millions of people.