Help With a Mess of a Separable Equation

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Homework Help Overview

The discussion revolves around solving an initial value problem related to the Michaelis-Menten equation, which models the amount of a chemical reactant over time. Participants are attempting to derive an implicit solution for the differential equation given specific constants.

Discussion Character

  • Exploratory, Mathematical reasoning, Problem interpretation

Approaches and Questions Raised

  • Participants discuss the integration process required to solve the differential equation, with some questioning the correctness of the antiderivative and the presence of a missing minus sign. There are attempts to clarify the relationship between S and t through implicit solutions, and some participants express uncertainty about the integration constants and initial conditions.

Discussion Status

The discussion is ongoing, with participants providing guidance on how to approach the integration and the implications of the initial conditions. There is recognition of differing interpretations of the implicit solution, and some participants are working through the implications of their findings without reaching a consensus.

Contextual Notes

Participants note the challenge of expressing the solution in terms of elementary functions and the necessity of using the Lambert W-function. There is also mention of the initial condition S(0) = S0, which is critical for determining the constant of integration.

cowmoo32
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Homework Statement


Let S(t) represent the amount of a chemical reactant present at time t, where t>= 0. Assume that S(t) can be determined by solving the initial value problem
http://webwork.math.ncsu.edu/webwork2_files/tmp/equations/21/885ac2eff6f65b363662233870e25e1.png

where a, K, and S0 are positive constants. Obtain an implicit solution of the initial value problem. (The differential equation, often referred to as the Michaelis-Menten equation, arises in the study of biochemical reactions.)


The Attempt at a Solution


[itex]\frac{dS}{dt}[/itex] = [itex]\frac{aS}{K + S}[/itex]

[itex]\int[/itex][itex]\frac{K + S}{aS}[/itex] = [itex]\int[/itex]dt

ln(aS)([itex]\frac{S^2}{2}+KS[/itex]) = t

I'm not even sure how to begin to solve for S
 
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cowmoo32 said:
...where a, K, and S0 are positive constants. Obtain an implicit solution of the initial value problem. (The differential equation, often referred to as the Michaelis-Menten equation, arises in the study of biochemical reactions.)...

Technically, if all you need is an implicit solution, then you're almost done - you never need to solve for S(t)... With an implicit solution, all you need is an equation which relates S and t. S and t are related by the expression you came to at the end: ln(aS)(S22+KS) = t. Moreover, that ODE doesn't have a solution S(t) in terms of elementary functions. You need the Lambert W-function to express it.

However, I would caution you that your integral seems to be missing a minus sign. Moreover, when I come up with the implicit solution, I get a completely different answer...

[tex] \int -\frac{K+S}{aS}dS=\int dt\\<br /> \Rightarrow \int -\frac{K}{aS}-\frac{S}{aS}dS=t+c\\<br /> \Rightarrow \int -\frac{K}{aS}-\frac{1}{a}dS=t+c\\<br /> \Rightarrow -\frac{1}{a}(K\ln (S(t))+S(t))=t+C[/tex]

(I'm not sure where you went wrong, but this is what you should be doing.)
Now, can you see what you need to do? Your constant of integration C is still there, but you have an initial condition [itex]S(0)=S_0[/itex]...
 
Last edited:
cowmoo32 said:
[itex]\int[/itex][itex]\frac{K + S}{aS}[/itex] = [itex]\int[/itex]dt

ln(aS)([itex]\frac{S^2}{2}+KS[/itex]) = t

That antiderivative isn't correct. You can't do
$$\int \frac{K+S}{aS}dS = \int\frac 1 {aS}dS\int K+S\, dS$$












4
 
christoff said:
Technically, if all you need is an implicit solution, then you're almost done - you never need to solve for S(t)... With an implicit solution, all you need is an equation which relates S and t. S and t are related by the expression you came to at the end: ln(aS)(S22+KS) = t. Moreover, that ODE doesn't have a solution S(t) in terms of elementary functions. You need the Lambert W-function to express it.

However, I would caution you that your integral seems to be missing a minus sign. Moreover, when I come up with the implicit solution, I get a completely different answer...

[tex] \int -\frac{K+S}{aS}dS=\int dt\\<br /> \Rightarrow \int -\frac{K}{aS}-\frac{S}{aS}dS=t+c\\<br /> \Rightarrow \int -\frac{K}{aS}-\frac{1}{a}dS=t+c\\<br /> \Rightarrow -\frac{1}{a}(K\ln (S(t))+S(t))=t+C[/tex]

(I'm not sure where you went wrong, but this is what you should be doing.)
Now, can you see what you need to do? Your constant of integration C is still there, but you have an initial condition [itex]S(0)=S_0[/itex]...
I'll give it another go and see what I come up with.

LCKurtz said:
That antiderivative isn't correct. You can't do
$$\int \frac{K+S}{aS}dS = \int\frac 1 {aS}dS\int K+S\, dS$$
You're right. I meant to split them into two fractions, not separate the numerator from the denominator.
 
ok, so I get [tex] -\frac{K}{a}(\ln (S(t))+S(t)=t+C[/tex]

Substituting S(0)=S0. I can't get the tex code correct, but I'm replacing S(t) with S0. When I solve for C, I get the entire equation =0, which isn't correct.
 
cowmoo32 said:
ok, so I get


[tex] -\frac{K}{a}(\ln (S(t))+S(t)=t+C[/tex]

Substituting S(0)=S0. I can't get the tex code correct, but I'm replacing S(t) with S0. When I solve for C, I get the entire equation =0, which isn't correct.

That should be$$-\frac{1}{a}(K\ln S(t)+S(t))=t+C$$
When you put ##t=0## and ##S(0) = S_0## in that equation you get$$
-\frac{1}{a}(K\ln (S_0)+S_0)=C$$Put that in for ##C## in the top equation.
 

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