In a connected graph G with distinct vertices u and v, the minimum size of a connected subgraph containing both u and v must include a path connecting them. The size can refer to either the number of edges or vertices, but typically, it is the number of edges that is considered. Since u and v are distinct, the smallest connected subgraph must have at least a length of 2, meaning it cannot simply consist of an edge between them. The discussion highlights that the minimum size can vary based on the graph's structure, emphasizing the need for clarity in defining "size" in this context. Understanding the properties of connected graphs is crucial for determining the minimum size of subgraphs containing specified vertices.