How is Cdc6 only synthesized at G1?

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In summary, the protein Cdc6 is a key player in regulating cell division, with high levels present at the end of mitosis and beginning of G1. It is then destroyed during the S phase and not formed until the next G1. The specific mechanisms for its synthesis and destruction are outlined in cell biology textbooks, such as the one cited.
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jaumzaum
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Cdc6 is one of the proteins that control when the cell is going to divide. It is in high concentration at the end of mitosis and beginning of G1 and it's destroyed after the S starts. My question is, how is that made? How is the protein synthesized only in G1 and how is it destroyed afterwards and it not formed until the next G1.
 
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Related to How is Cdc6 only synthesized at G1?

1. How is Cdc6 only synthesized at G1?

Cdc6 is a protein that plays a crucial role in the initiation of DNA replication in eukaryotic cells. It is synthesized at the G1 phase of the cell cycle, which is the phase where cells prepare for DNA replication. The synthesis of Cdc6 is tightly regulated by various factors to ensure that it is only produced during G1.

2. What factors regulate the synthesis of Cdc6 at G1?

The synthesis of Cdc6 at G1 is regulated by a complex network of factors, including transcription factors, cell cycle regulators, and DNA damage response proteins. These factors work together to control the expression of the gene that encodes Cdc6 and ensure that it is only produced at the right time.

3. Why is it important for Cdc6 to be synthesized only at G1?

Cdc6 is a key player in the initiation of DNA replication, which is a highly regulated process. If Cdc6 is synthesized at the wrong time, it can lead to errors in DNA replication and potentially harmful mutations. By controlling the synthesis of Cdc6 at G1, cells can ensure that DNA replication occurs accurately and efficiently.

4. How is the synthesis of Cdc6 at G1 regulated in different cell types?

The regulation of Cdc6 synthesis at G1 can vary between different cell types. For example, in yeast cells, Cdc6 is regulated by a specific transcription factor called SBF. In human cells, Cdc6 is regulated by multiple factors, including the tumor suppressor protein p53 and the retinoblastoma protein. The specific regulatory mechanisms may differ, but the overall goal is to ensure that Cdc6 is only produced at G1.

5. Are there any diseases or disorders associated with dysregulation of Cdc6 synthesis at G1?

Yes, dysregulation of Cdc6 synthesis at G1 has been linked to various diseases and disorders, including cancer. Mutations in the genes that regulate Cdc6 synthesis can lead to abnormal levels of Cdc6, which can disrupt the cell cycle and contribute to the development of cancer. Additionally, certain viruses, such as human papillomavirus, can manipulate the expression of Cdc6 to promote their own replication and cause diseases like cervical cancer.

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