The number of spanning trees in a graph cannot be determined solely from the number of nodes and branches. However, if the graph's vertices and edges are labeled, the "deletion-contraction" theorem can be applied to recursively calculate the number of spanning trees. This theorem states that the total number of spanning trees is the sum of the spanning trees obtained by deleting or contracting an edge. Additionally, calculating a cofactor of the graph's Laplacian matrix is another method to find the number of spanning trees, but it also requires labeling the graph. Understanding these methods is essential for accurately determining the number of spanning trees in a given graph.