Hydrolysis Reaction: Aspartame & Water Breakdown

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SUMMARY

The hydrolysis reaction of aspartame involves the breakdown of the molecule into phenylalanine and a carboxylic acid when reacted with water. This reaction specifically occurs at the amide functionality of aspartame. The mechanism can be found in standard organic chemistry textbooks, and purification of the resulting solution can be achieved through established methods to remove impurities.

PREREQUISITES
  • Understanding of organic chemistry principles, specifically hydrolysis reactions.
  • Familiarity with amide and carboxylic acid functional groups.
  • Knowledge of purification techniques in organic chemistry.
  • Basic comprehension of aspartame's chemical structure.
NEXT STEPS
  • Study the hydrolysis mechanism of amides in organic chemistry.
  • Research purification methods for organic compounds, such as recrystallization or chromatography.
  • Learn about the properties and applications of phenylalanine in biochemistry.
  • Explore the chemical structure and properties of aspartame in detail.
USEFUL FOR

Students and professionals in organic chemistry, particularly those interested in hydrolysis reactions and the breakdown of artificial sweeteners like aspartame.

BiggerStronger
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I am a newbie to organic chemistry. Can someone please outline a hydrolysis reaction of aspartame...I.E. parts of aspartame to parts of water.

I would greatly appreciate it. :)

What would be left over after the hydrolysis reaction. I read it should be phenylalanine...How would you purify the solution of any inpurities?
 
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It's a pretty standard hydrolysis, you can find the mechanism in any O-chem text. There's really no use in explaining it step by step verbally on a message board.

Notice the structure of aspartame. They hydrolysis occurs at the amide functionality which cleaves the molecule into a carboxylic acid and an amine, the latter of which is phenylalanine.
 

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