Sorry! said:
So how exactly do these 2 stories prove my point wrong?
There are approximately 4 256 836 vegans in America alone. I've seen you give me 2 stories of people who were quite obviously misinformed and not maintaining a nutrious life-style while following their vegan diet. I don't think it's dangerous.
you want more? i already gave you the study on 7th day adventists, and that was even a co-mingling with lactoovovegetarians and some omnivores.
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=15189123&query_hl=2
Annu Rev Nutr. 2004;24:299-326.
Vitamin B12 deficiency as a worldwide problem.
Stabler SP, Allen RH.
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
Sally.Stabler@UCHSC.edu
Pernicious anemia is a common cause of megaloblastic anemia throughout the world and especially in persons of European or African descent. Dietary deficiency of vitamin B12 due to vegetarianism is increasing and causes hyperhomocysteinemia. The breast-fed infant of a vitamin B12-deficient mother is at risk for severe developmental abnormalities, growth failure, and anemia. Elevated methylmalonic acid and/or total homocysteine are sensitive indicators of vitamin B12-deficient diets and correlate with clinical abnormalities. Dietary vitamin B12 deficiency is a severe problem in the Indian subcontinent, Mexico, Central and South America, and selected areas in Africa. Dietary vitamin B12 deficiency is not prevalent in Asia, except in vegetarians. Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae.
Publication Types:
* Review
PMID: 15189123 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=15171677&query_hl=2
Can Fam Physician. 2004 May;50:743-7.
Vitamin B12 deficiency. Prevalence among South Asians at a Toronto clinic.
Gupta AK, Damji A, Uppaluri A.
Rexdale Community Health Centre, Ontario.
patriciabaltazar@hotmail.com
OBJECTIVE: To estimate the prevalence of vitamin B12 deficiency in adult South Asian patients. DESIGN: Retrospective chart review. SETTING: Family practice clinic in Toronto, Ont. PARTICIPANTS: Records of 988 South Asian patients. INTERVENTION: Of 1000 randomly selected records, we found 988 charts. From charts with at least one documented B12 level, we extracted data on age, mean corpuscular volume (MCV), hemoglobin and ferritin levels, and diet (if available). Descriptive and analytic statistics were calculated. MAIN OUTCOME MEASURES: Levels of serum B12 and factors associated with low levels of B12. RESULTS: B12 results were documented in 49% of charts; 46% of results showed deficiency. Patients older than 65 and vegetarians were more likely to be B12 deficient. Low serum B12 levels were positively correlated with low hemoglobin and ferritin levels and poorly correlated with low MCV levels. CONCLUSION: Many more South Asian patients than patients in the general population have vitamin B12 deficiency. A vegetarian diet seems a strong risk factor. A single low result, however, might not indicate true B12 deficiency.
PMID: 15171677 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=15153278&query_hl=2
Public Health Nutr. 2004 May;7(3):467-72.
Homocysteine and cobalamin status in German vegans.
Waldmann A, Koschizke JW, Leitzmann C, Hahn A.
Institute of Food Science, University of Hanover, Wunstorfer Strasse 14, D-30453 Hanover, Germany.
OBJECTIVE: The study aimed to evaluate the homocysteine and cobalamin status of German vegans and determine whether the intake of very small amounts of foods of animal origin can improve this status. DESIGN AND SETTING: Cross-sectional study, Germany. SUBJECTS: The dietary and nutritional intakes of 131 vegans (73 women, 58 men; age range: 20.2-82.1 years) were evaluated using a general questionnaire and two food-frequency questionnaires. RESULTS: The prevalence of inadequate cobalamin status in volunteers of the German Vegan Study was 28.2%, and that of hyperhomocysteinaemia, 38.1%. Moderate vegans were affected to a lesser extent than were strict vegans. Duration of veganism and cobalamin concentration were inversely correlated (Spearman's r=-0.175, P=0.047). Folate concentration and erythrocyte aspartic acid aminotransferase activity were not correlated with plasma homocysteine concentration, but duration of veganism correlated positively with homocysteine concentration (Spearman's r=0.319, P<0.001). Cobalamin and homocysteine concentrations were inversely correlated (when controlling for duration of veganism; r=-0.602, P<0.001). CONCLUSION: Cobalamin status needs to be improved in order to minimise the risk of hyperhomocysteinaemia.
PMID: 15153278 [PubMed - indexed for MEDLINE]
long-term damage to kids subjected to these quacky diets:
http://www.ncbi.nlm.nih.gov/entrez/...&dopt=Abstract&list_uids=10197567&query_hl=14
Am J Clin Nutr. 1999 Apr;69(4):664-71.
Risk of persistent cobalamin deficiency in adolescents fed a macrobiotic diet in early life.
van Dusseldorp M, Schneede J, Refsum H, Ueland PM, Thomas CM, de Boer E, van Staveren WA.
Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Netherlands.
Marijke.vandusseldorp@staff.nutepi.wau.nl
BACKGROUND: Cobalamin deficiency has been described in children consuming macrobiotic diets. OBJECTIVE: We investigated whether moderate consumption of animal products is sufficient for achieving normal cobalamin function in 73 adolescents who had received a macrobiotic diet until 6 y of age and had then switched to a lactovegetarian, lactoovovegetarian, or omnivorous diet (macrobiotic adolescents). DESIGN: Hematologic indexes and serum concentrations of methylmalonic acid (MMA), total homocysteine (tHcy), and folate were measured. Current consumption frequency of animal products and cobalamin intake from dairy products were assessed by questionnaire. Data from 94 age-matched adolescents who received an omnivorous diet from birth were used as a reference. RESULTS: Serum cobalamin concentrations were significantly lower and concentrations of MMA and folate and mean corpuscular volume (MCV) were significantly higher in macrobiotic adolescents than in control adolescents: of macrobiotic adolescents, 21% had abnormal MMA concentrations (>0.41 micromol/L), 37% had abnormal cobalamin concentrations (<218 pmol/L), 10% had abnormal tHcy concentrations (> 12.8 micromol/L), and 15% had abnormal MCV (> 89 fL). In macrobiotic adolescents, dairy products (200 g milk or yogurt and 22 g cheese/d) supplied on average 0.95 microg cobalamin/d; additionally, these adolescents consumed fish, meat, or chicken 2-3 times/wk.
In girls, meat consumption contributed more to cobalamin status than the consumption of dairy products, whereas in boys these food groups were equally important. CONCLUSIONS: A substantial number of the formerly strict macrobiotic adolescents still had impaired cobalamin function.
Thus, moderate consumption of animal products is not sufficient for restoring normal cobalamin status in subjects with inadequate cobalamin intake during the early years of life.
PMID: 10197567 [PubMed - indexed for MEDLINE]
you can use this one as a positive if you like:
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=8172120&query_hl=14
Am J Clin Nutr. 1994 May;59(5 Suppl):1176S-1181S.
Vegetarian diets and children.
Sanders TA, Reddy S.
Department of Nutrition and Dietetics, Kings College, University of London, England.
The diets and growth of children reared on vegetarian diets are reviewed. Excessive bulk combined with low energy density can be a problem for children aged < or = 5 y and can lead to imparied growth. Diets that have a high content of phytate and other modifiers of mineral absorption are associated with an increased prevalence of rickets and iron-deficiency anemia. Vitamin B-12 deficiency is a real hazard in unsupplemented or unfortified vegan and vegetarian diets. It is suggested that vegans and vegetarians should use oils with a low ratio of linoleic to linolenic acid in view of the recently recognized role of docosahexaenoic acid in visual functioning. If known pitfalls are avoided, the growth and development of children reared on both vegan and vegetarian diets appears normal.
Publication Types:
* Review
PMID: 8172120 [PubMed - indexed for MEDLINE]
and there are other good reasons to eat meat:
Creatine monohydrate in resistant depression: a preliminary study.
Roitman S, Green T, Osher Y, Karni N, Levine J.
Ness Ziona Mental Health Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
OBJECTIVES: Creatine plays a pivotal role in brain energy homeostasis, and altered cerebral energy metabolism may be involved in the pathophysiology of depression. Oral creatine supplementation may modify brain high-energy phosphate metabolism in depressed subjects. METHODS: Eight unipolar and two bipolar patients with treatment-resistant depression were treated for four weeks with 3-5 g/day of creatine monohydrate in an open add-on design. Outcome measures were the Hamilton Depression Rating Scale, Hamilton Anxiety Scale, and Clinical Global Impression scores, recorded at baseline and at weeks 1, 2, 3 and 4. RESULTS: One patient improved considerably after one week and withdrew. Both bipolar patients developed hypomania/mania. For the remaining seven patients, all scale scores significantly improved. Adverse reactions were mild and transitory. CONCLUSIONS: This small, preliminary, open study of creatine monohydrate suggests a beneficial effect of creatine augmentation in unipolar depression, but possible precipitation of a manic switch in bipolar depression.
http://www.ajcn.org/cgi/content/full/72/3/762
Am J Clin Nutr. 2000 Sep;72(3):762-9.
Signs of impaired cognitive function in adolescents with marginal cobalamin status.
Louwman MW, van Dusseldorp M, van de Vijver FJ, Thomas CM, Schneede J, Ueland PM, Refsum H, van Staveren WA.
Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Netherlands.
BACKGROUND: Lack of cobalamin may lead to neurologic disorders, which have been reported in strict vegetarians. OBJECTIVE: The objective of this study was to investigate whether cognitive functioning is affected in adolescents (aged 10-16 y) with marginal cobalamin status as a result of being fed a macrobiotic diet up to an average age of 6 y. DESIGN: Data on dietary intake, psychological test performance, and biochemical variables of cobalamin status were collected from 48 adolescents who consumed macrobiotic (vegan type) diets up to the age of 6 y, subsequently followed by lactovegetarian or omnivorous diets, and from 24 subjects (aged 10-18 y) who were fed omnivorous diets from birth onward. Thirty-one subjects from the previously macrobiotic group were cobalamin deficient according to their plasma methylmalonic acid concentrations. Seventeen previously macrobiotic subjects and all control subjects had normal cobalamin status. RESULTS: The control subjects performed better on most psychological tests than did macrobiotic subjects with low or normal cobalamin status. A significant relation between test score and cobalamin deficiency (P: = 0.01) was observed for a test measuring fluid intelligence (correlation coefficient: -0.28; 95% CI: -0.48, -0.08). This effect became more pronounced (P: = 0.003) within the subgroup of macrobiotic subjects (correlation coefficient: -0.38; 95% CI: -0.62, - 0.14). CONCLUSION: Our data suggest that cobalamin deficiency, in the absence of hematologic signs, may lead to impaired cognitive performance in adolescents.
PMID: 10966896 [PubMed - indexed for MEDLINE]
Med J Aust. 1979 Jul 14;2(1):1-3.Links
Brain damage in infancy and dietary vitamin B12 deficiency.
Wighton MC, Manson JI, Speed I, Robertson E, Chapman E.
A case of the exclusively breast-fed infant of a vegetarian mother is reported. Neurological deterioration commenced between three and six months of age, and progressed to a comatose premoribund state by the age of nine months. Investigations revealed a mild nutritional vitamin B12 deficiency in the mother, and a very severe nutritional B12 deficiency in the infant, with severe megaloblastic anaemia. Treatment of the infant with vitamin B12 resulted in a rapid clinical and haematological improvement, but neurological recovery was incomplete. Evidence is presented that dietary B12 deficiency was the sole cause of the infant's deterioration, and the literature relating to the condition is reviewed. It is recommended that all strict vegetarians (vegans), especially women in the child-bearing age group, take vitamin B12 supplements.
PMID: 502936 [PubMed - indexed for MEDLINE]
Z Geburtshilfe Neonatol. 2007 Aug;211(4):157-61.Click here to read Links
[Maternal vitamin B12 deficiency: cause for neurological symptoms in infancy]
[Article in German]
Lücke T, Korenke GC, Poggenburg I, Bentele KH, Das AM, Hartmann H.
Klinik für Kinder und Jugendliche, Medizinische Hochschule Hannover.
BACKGROUND: Symptoms of Vitamin B (12) deficiency in infancy include growth retardation, regression of psychomotor development, muscular hypotonia and brain atrophy. Besides an inappropriate vegetarian diet of the infants, a vegan diet or a pernicious anaemia of the mother may lead to an insufficient vitamin B (12) supply of the child. PATIENTS AND METHODS: We report here the neurological symptoms of 4 fully breast-fed infants from mothers on vegan diet or with pernicious anaemia. DISCUSSION AND CONCLUSION: Vitamin B (12) deficiency can easily be diagnosed by detection of methylmalonic acid when measuring the organic acids in urine. Vitamin B (12) deficiency should be avoided or diagnosed as early as possible since a supplementation of mother and child can prevent neurological symptoms of the baby. Furthermore, the neurological symptoms of the infant with manifest vitamin B (12) deficiency are (partially) reversible.
PMID: 17729202 [PubMed - indexed for MEDLINE]
http://www.ajcn.org/cgi/content/full/78/1/3
Vegetarianism and vitamin B-12 (cobalamin) deficiency
can malnutrition make moms act crazy? why yes, yes it can.
N Engl J Med. 1988 Jun 30;318(26):1720-8.Links
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH.
Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY 10032.
Among 141 consecutive patients with neuro-psychiatric abnormalities due to cobalamin deficiency, we found that 40 (28 percent) had no anemia or macrocytosis. The hematocrit was normal in 34, the mean cell volume was normal in 25, and both tests were normal in 19. Characteristic features in such patients included paresthesia, sensory loss, ataxia, dementia, and psychiatric disorders; longstanding neurologic symptoms without anemia; normal white-cell and platelet counts and serum bilirubin and lactate dehydrogenase levels; and markedly elevated serum concentrations of methylmalonic acid and total homocysteine. Serum cobalamin levels were above 150 pmol per liter (200 pg per milliliter) in 2 patients, between 75 and 150 pmol per liter (100 and 200 pg per milliliter) in 16, and below 75 pmol per liter (100 pg per milliliter) in only 22. Except for one patient who died during the first week of treatment, every patient in this group benefited from cobalamin therapy. Responses included improvement in neuropsychiatric abnormalities (39 of 39), improvement (often within the normal range) in one or more hematologic findings (36 of 39), and a decrease of more than 50 percent in levels of serum methylmalonic acid, total homocysteine, or both (31 of 31). We conclude that neuropsychiatric disorders due to cobalamin deficiency occur commonly in the absence of anemia or an elevated mean cell volume and that measurements of serum methylmalonic acid and total homocysteine both before and after treatment are useful in the diagnosis of these patients.
PMID: 3374544 [PubMed - indexed for MEDLINE]
Nutr Rev. 1996 Dec;54(12):382-90.Links
Folate, vitamin B12, and neuropsychiatric disorders.
Bottiglieri T.
Kimberly H. Courtwright and Joseph W. Summers Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas, USA.
Folate and vitamin B12 are required both in the methylation of homocysteine to methionine and in the synthesis of S-adenosylmethionine. S-adenosylmethionine is involved in numerous methylation reactions involving proteins, phospholipids, DNA, and neurotransmitter metabolism. Both folate and vitamin B12 deficiency may cause similar neurologic and psychiatric disturbances including depression, dementia, and a demyelinating myelopathy. A current theory proposes that a defect in methylation processes is central to the biochemical basis of the neuropsychiatry of these vitamin deficiencies. Folate deficiency may specifically affect central monoamine metabolism and aggravate depressive disorders. In addition, the neurotoxic effects of homocysteine may also play a role in the neurologic and psychiatric disturbances that are associated with folate and vitamin B12 deficiency.
PMID: 9155210 [PubMed - indexed for MEDLINE]