I think Mindscrape is misunderstanding the word "integrating factor". In particular, I cannot see what "variation of parameters" could have to do with "integrating factor". He seems to be confusing "integrating factor" with the method of "undetermined coefficients".
An "integrating factor" is a function of the variables which, if you multiply a differential equation by it, makes the equation "exact"- or, in other terms, if you multiply a differential by it, makes the differential and exact differential. To answer your question, bartsdalemc, no, there is no general method of determining whether an integrating factor involves only one or several of the variables. If there were, the problem of solving a general first order differential equation would become trivial- and, believe me, it is not!