I don't think this is necessarily true. Avogadro's Number is defined as the number of Carbon 12 atoms in 12 grams of Carbon 12. The gram is defined as 1/1000th the mass of the kilogram, which is a specific platinum-iridium artifact in France. Since it is not made of pure carbon 12, there is no reason to suppose that the ratio of the gram to the mass of a carbon 12 atom is rational, and it is therefore possible (probable, even, it seems given that the rationals are a set of measure zero) that it is irrational. In truth it changes over time as the kilogram loses mass slowly due to evaporation and unknown causes that have reduced its mass over the years.