Isotope Exchange Deuterium: Mechanism & Labeling

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Deuterium, being heavier than hydrogen, allows for the differentiation of metal bonds through isotopic exchange, which can be analyzed using infrared spectroscopy and mass spectrometry. The discussion explores methods for replacing hydrogen with deuterium, including dehydrogenation followed by the addition of deuterated solvents like heavy water or CDCl3, and simply dissolving compounds in deuterated solvents. There is uncertainty about the effectiveness of these methods, prompting questions about the underlying mechanism. Additionally, the distinction between isotope exchange and isotope labeling is raised, indicating a need for clarification. The consensus leans towards the idea that for simple M-H bonds, dissolving in deuterated solvents may suffice for deuterium incorporation.
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Deuterium is heavier then Hydrogen so a metal bonded to H vs. C can be determined by isotopic exchange and then using Infrared Spectroscopy/mass spec. But how do you replace hydrogen with deuterium?

a.Dehydrogenation and then add deuterated solvents (heavy water or CDCl3 ..deuterated chloroform)?
b.Just dissolve cpd in deuterated solvent?

I have doubts about the above mentioned applications…so how what is the meachanism?

Thanks for your help

Wait …what is the difference between isotope exchange vs. isotope labeling?

Thanks
 
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opos I think this should have been under the homework "other sciences" section...So sorry!

back to the question I think if you have some thing as simple as a M-H bond you can just dissolve it is deuterated solvents! ~ right?
 

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