Traveling near the speed of light would cause cosmic background radiation (CMBR) to blue-shift, potentially transforming it into x-rays and gamma rays, which poses challenges for interstellar travel. The discussion highlights that the anisotropy of the CMBR indicates that neither the Earth nor the Milky Way is a comoving body, as they both experience different velocities relative to the CMBR. The Earth's speed relative to the CMBR is approximately 627 km/s, while its speed relative to the Sun is about 30 km/s. This means that waiting for a moment of rest relative to the CMBR is not feasible. The concept of a preferred frame of reference is explored, suggesting that while local frames can simplify physics, no absolute preferred frame exists according to the laws of physics.