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Markov Chains and absorption probabilites

  1. Feb 4, 2013 #1
    Could someone please help me with this question?

    A single-celled organism contains N particles, some of which are of type A, the others of
    type B . The cell is said to be in state i where 0<=i<=N if it contains exactly i particles
    of type A. Daughter cells are formed by cell division, but rst each particle replicates itself;
    the daughter cell inherits N particles chosen at random from the 2i particles of type A
    and 2N-2i of type B in the parent cell.

    Find the absorption probabilities and expected times to absorption for the case N = 3.


    I so far have that the absorbing states are i=0, i=3 but have no idea where to go from there
     
  2. jcsd
  3. Feb 4, 2013 #2

    mfb

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    For N=3, you can calculate the transition matrix manually. Many entries are 0, and some others follow from symmetry, so you just need 2 interesting entries.
     
  4. Feb 4, 2013 #3
    how do i calculate the entries though, thats where i'm stuck at the moment, i know of course the lines for starting in state 0 and 3, but have no clue about 1 or 2, once i know that the rest of the question becomes fairly trivial, could you push me in the right direction?
     
  5. Feb 4, 2013 #4

    mfb

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    i=1 leads to AABBBB in the cell before splitting. If you randomly pick 3 of them, what is the probability of getting 0 (,1,2,3) times A?
     
  6. Feb 4, 2013 #5
    oh is that standard binomial? so probability of going from state 1 to 0 would be (2/3)^3 which is 8/27 then do the same for the other states? or am i missing something?
     
  7. Feb 4, 2013 #6
    i really don't understand the probabilities of getting to the other states, do i not need to also consider what the other cell will contain or is that irrelevant?
     
  8. Feb 5, 2013 #7
    I think i finally get it, so probability of 0 A's is equal to
    (2/3)*(3/5)*(1/2) which is the probability of selecting a B each time
    Then follow the same method for 1 A taking into account whether you chose the A first, second or third? I hope thats right
     
  9. Feb 5, 2013 #8

    mfb

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    That is correct.
     
  10. Feb 5, 2013 #9
    Thanks for the help
     
  11. Feb 19, 2014 #10
    I also have difficulty in this question.I have calculated that the probabilty of getting 0 'a's is 1/5...probability of getting 1 'a' is 3/5 and probability of getting 2 'a' is 1/5. What is the transition matrix and what are the absorption probabilities?
    thank you
     
  12. Feb 20, 2014 #11

    Ray Vickson

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    If you start with AABBBB and pick three at random, you are looking at the "hypergeometric distribution", which is the probability for choosing k of type A from a population of 2A and 4B, when you choose three altogether. See, eg., http://en.wikipedia.org/wiki/Hypergeometric_distribution or http://mathworld.wolfram.com/HypergeometricDistribution.html .
     
  13. Feb 21, 2014 #12
    thank you..i have already found the probabilities but how to find the transition matrix please?
     
  14. Feb 21, 2014 #13

    Ray Vickson

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    Work it out for yourself. If you start in state i = 1, what are the possible next states you can reach in one step? What are the probabilities of going to those various states in one step? Once you have answered those questions you will have worked out what is the i = 1 row of the transition matrix. You get the other rows in a similar way. There are no shortcuts; you have to sit down and do it all, step-by-step; and you will only learn how by doing it yourself.
     
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