In my experience with MMA trying to use subscripts is often more trouble than it is worth.
What I would do is
t0 = 0; t3 = 5; NMinimize[{
Integrate[0.25`(E^(-0.015`*t)*(-4044.4444444444443`*E^(-0.015`*t1) + E^(0.015`*t)*(4044.4444444444443` - 66.6666666666667`*t) + 66.6666666666667`*E^(0.015`*t1)*t1))^2, {t, t0, t1}] +
Integrate[0.25`(E^(-0.015`*t)*(-4044.4444444444443`*E^(-0.015`*t2) + E^(0.015`*t)*(4044.4444444444443` - 66.6666666666667`*t) + 66.6666666666667`*E^(0.015`*t2)*t1))^2, {t, t1, t2}] +
Integrate[0.25`(E^(-0.015`*t)*(-4044.4444444444443`*E^(-0.015`*t3) + E^(0.015`*t)*(4044.4444444444443` - 66.6666666666667`*t) + 66.6666666666667`*E^(0.015`*t3)*t1))^2,{t, t2, t3}],
t0 <= t1 && t1 <= t2 && t2 <= t3}, {t1, t2}]
and it gives you an answer in a few seconds.