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geo_alchemist
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under what circumstances phenol forms phenolate with max yield
Max Yield Phenolate Formation with Phenol
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Discussion Overview
The discussion revolves around the conditions under which phenol can form phenolate with maximum yield. Participants explore various factors influencing this reaction, including pH levels and the choice of base used in the process.
Discussion Character
- Exploratory, Technical explanation, Debate/contested
Main Points Raised
- One participant suggests that high pH is necessary for phenol to form phenolate, noting that phenol is a weak acid.
- Another participant emphasizes the need for high pH and recommends adding excess strong base to achieve maximum yield.
- A different participant acknowledges the weak acidic nature of phenol but seeks more specific circumstances for optimal phenolate formation.
- One participant proposes using sodium hydride, a very strong base, instead of more commonly used bases like sodium or potassium hydroxide, particularly in tetrahydrofuran at low temperatures, to achieve extreme conditions for phenolate formation.
Areas of Agreement / Disagreement
Participants generally agree that high pH and the use of a strong base are important for maximizing phenolate yield, but there is no consensus on the specific conditions or the necessity of using particular bases.
Contextual Notes
Discussion includes varying assumptions about the strength of bases and the specific conditions required for optimal yield, which may depend on the reaction environment and other factors.
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