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What are the mechanisms of immune response after Covid vaccination?
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[QUOTE="Ygggdrasil, post: 6522058, member: 124113"] Here's a passage from an article on adaptive immunity to SARS-CoV-2 that has a decently good explanation: [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803150/[/URL] (The full article is a great reference on the immunology of SARS-CoV-2 and very much worth a read) In other words, vaccines will primarily protect from infection through the production of neutralizing antibodies that can bind to an inactivate the SARS-CoV-2 virus. If these antibodies are not present in high enough amounts (due to waning immunity over time) or are not as effective (due to the emergence of new variants), [URL='https://www.nature.com/articles/d41586-021-00367-7']T-cells can protect against severe disease[/URL] by helping to control the infection by culling infected cells and stimulating memory B cells to make antibodies again. Consistent with this model, new research examining the [URL='https://www.nature.com/articles/s41591-021-01432-4']correlates of protection for SARS-CoV-2[/URL] suggests that the amounts of neutralizing antibodies correlate well with protection against infection. Note that this research does not necessarily suggest that neutralizing antibodies are the only source of protection; production of an antibody response depends on an efficient CD4+ T-cell response, so the presence of neutralizing antibodies reflects both a functioning antibody response and a functioning T-cell response.[URL='https://www.nature.com/articles/s41586-020-03041-6'] Experiments in animals [/URL]suggest that both the antibody response and the T-cell response help protect against infection. [/QUOTE]
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What are the mechanisms of immune response after Covid vaccination?
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