Mono-esterify a mono-phosphate salt group to a carboxylic acid

  • #1
Summary:
Organic Chemistry
I am interested to see if anyone knows the easiest way to mono-esterify a mono-phosphate salt group to a carboxylic acid.

How to facilitate the resultant -> product ?

CH3COOH + NaH2PO4 ‐> C2H4NaO5P + H20
Screenshot_20211017-151346_Molecular Constructor.jpg
 

Answers and Replies

  • #2
TeethWhitener
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You can google “acetyl phosphate preparation” to get several results on how the compound is prepared commercially. Generally, it goes through a transesterification of an organic acetate with phosphoric acid, rather than a direct reaction of acetic acid with a phosphate, though the latter will probably work at least a little bit under the right conditions. The compound itself isn’t likely to be particularly difficult to make, but the separation/isolation/general workup is probably where most of the optimization of the reaction happens.
 
  • #3
Thanks for the response,
Would you happen to have an optimal route to synthesis?
 
  • #4
TeethWhitener
Science Advisor
Gold Member
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Thanks for the response,
Would you happen to have an optimal route to synthesis?
I’m not going to be able to do better than a google search can.
 
  • #5
Thanks
 

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