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Peptide Bond Dissociation Temperaure

  1. Nov 27, 2015 #1
    This is more of a biochem question, but since there is not biochem forum, I'll ask it here.

    How much heat is required to break a peptide bond (not just denature the protein) in the absence of any catalysts?
  2. jcsd
  3. Nov 27, 2015 #2


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    Hello RP, :welcome:

    Not much by chemical standards: I found peptide bond dissociation energies are 8-10 kJ/mol.
    At room temperature, RT is already about 2.5 kJ/mol.
    Check out the Arrhenius equation
  4. Nov 27, 2015 #3


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