- #1

- 611

- 116

- Homework Statement
- What is the meaning behind the total volume of distribution and total body clearance concepts?

- Relevant Equations
- Concentration equations

Hi,

I was recently reading through Systems Kinetic Modeling notes and am struggling to understand the concepts of

As far as I understand, the total volume of distribution ## V_c ## is the "volume of the compartment into which the substance has distributed itself" and can be written as:

[tex] V_c = \frac{\text{Dose given}}{\text{Initial concentration}} = \frac{D}{C_p (0)} [/tex]

is this correct?

Then, I don't understand the intuition between the connection between ## V_c ## and the total body clearance ## Cl_{total} ##, which can be written as ## Cl_{total} = k_e V_c ## where ## k_e ## is the elimination rate. We weren't told about it during the lectures and I just found the formulae above on the internet.

Is this because the total body clearance is supposed to measure the volume of substance

Any help would be greatly appreciated.

I was recently reading through Systems Kinetic Modeling notes and am struggling to understand the concepts of

**total volume of distribution**and**total body clearance**.As far as I understand, the total volume of distribution ## V_c ## is the "volume of the compartment into which the substance has distributed itself" and can be written as:

[tex] V_c = \frac{\text{Dose given}}{\text{Initial concentration}} = \frac{D}{C_p (0)} [/tex]

is this correct?

Then, I don't understand the intuition between the connection between ## V_c ## and the total body clearance ## Cl_{total} ##, which can be written as ## Cl_{total} = k_e V_c ## where ## k_e ## is the elimination rate. We weren't told about it during the lectures and I just found the formulae above on the internet.

Is this because the total body clearance is supposed to measure the volume of substance

__within the plasma__that is cleared per unit time?Any help would be greatly appreciated.