I've done some calculations. At first glimpse, yes it sounds very nice, that with missiles you can attack way outside laser range... On the other hand, based on molar heat and weight of titanium, it looks like to me, that actually melting down a kg projectile only requires a few MJ... while boosting it to only 10km/s requires scale more power. That shows that even with the low efficiency of lasers (especially vs reflective armor) actually taking out the missile from a safe distance requires lesser power than sending a long range missile, that can track a manuevering target. I looking for a plausible explanation to justify the roles of missiles and agility to dodge shrapnels... I have listed a few things that can be the weakness of laser defence, my question is, what could be the main explanation that sounds plausible from the viewpoint of physics and engineering? Cooldown time : While we already have TW lasers, but what i read about National Ignition Facility, it looks like they need hours to cool down after a shot. Is there any hope that it could change without some unobtanium? Fragile mirrors : You need large mirrors to focus a beam precisely. After they heated by the shot they might be damaged by a much lesser laser? In this case, the lasers main role could be simply weaken the defence systems (either with a long range duel, or just after the first wave of missiles reach a distance of a few thousand km) while kinetics still have a big role. Jamming : it requires lesser energy than taking out an armored target (30 fighters, but they are so small we cant track them!) On the other hand it could be countered by narrow band filtering (although that also filters out much of the heat signs...) or erecting lots of small probes. Although the main ship could use active radars (that isnt face toward the enemy ships jammers) to find theese targeting probes also.