The discussion centers on advancements in polymer physics and genetic sequencing, particularly the use of nanopores for DNA analysis. Participants highlight the potential of molecular dynamics simulation algorithms to model DNA and solvent interactions within nanopores, referencing recent successes in simulating membrane proteins with lipid bilayers. The conversation emphasizes the practicality of these techniques, suggesting they can be applied effectively in research settings.
PREREQUISITESResearchers in polymer physics, geneticists, and computational biologists interested in the intersection of nanopore technology and molecular dynamics simulations.
Nice, Alex. Molecular dynamics simulation algorithms have been making great strides lately, and I don't believe it's beyond hope that DNA+solvent inside and outside a nanopore can now be modeled. For example, membrane proteins with lipid bilayers and water have been modeled. Or, at least on very short timescales (micro-s ?) they can. Have you used this modeling technique in your research? Has anyone?Mark Harder said: