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Other Sciences
Biology and Medical
Calculating the Probability of Particles Traveling Through Different Size Pores
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[QUOTE="Jeffmoonchop, post: 6555758, member: 695411"] [B]Homework Statement::[/B] Not homework, but I want to calculate the probability of different size spheres traveling through different size pores. [B]Relevant Equations::[/B] V=4/3πr^3 volume of sphere. Volume of 60nm diameter particle = 1.13x10^5 nm^3. Volume of 70nm particle = 1.8x10^5 nm^3 Hi all, this is in relation to biotech. I develop lipid nanoparticle delivery vehicles for mRNA delivery. There is a biological barrier for delivery to the liver known as sinusoidal fenestrae. Pores that vary in size from 80-120nm. We know that smaller particles are more likely to go through these pores. But I want to know how much more likely for example, a 60nm particle will fit through a 80nm pore vs a 70nm particle. Basically shooting a basketball through the hoop compared to a baseball. The problem is probably complex, as there are many variables, such as direction of travel, media current, positive pressure gradients etc. You can see that the volume of a 60nm particle is 61% of the volume of a 70nm particle. I'm unsure if we need to use momentum, as mass is obviously a lot greater for a 70nm particle, momentum means its less likely to be moved by outward forces towards the pore. Or if we only need diameter? I should probably note, the pores are less of a hoop, but a slight tunnel, around 5nm long. Appreciate any help. Thanks [/QUOTE]
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Calculating the Probability of Particles Traveling Through Different Size Pores
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