Regular perturbation nonlinear problem

Click For Summary
SUMMARY

The discussion centers on solving a system of nonlinear ordinary differential equations (ODEs) related to a drug-receptor binding model, specifically analyzing the effects of small perturbations characterized by the parameter ε. The original equations are transformed into a leading-order problem, but the nonlinearity remains unresolved. Participants suggest using numerical methods or series solutions to approximate the behavior of the solution, especially when dealing with parameter configurations such as γ = ε. The parameters α and β are crucial in the nondimensionalization process, with α being O(1) and limited information available for β and γ.

PREREQUISITES
  • Understanding of ordinary differential equations (ODEs)
  • Familiarity with perturbation methods in applied mathematics
  • Knowledge of asymptotic analysis techniques
  • Experience with numerical methods for solving nonlinear equations
NEXT STEPS
  • Explore numerical methods for solving nonlinear ODEs, such as Runge-Kutta methods
  • Learn about series solutions for differential equations, focusing on perturbation techniques
  • Investigate asymptotic analysis in the context of singular perturbation problems
  • Study drug-receptor binding models and their mathematical formulations
USEFUL FOR

Mathematicians, applied mathematicians, and researchers in pharmacokinetics or systems biology who are dealing with nonlinear differential equations and perturbation analysis.

Carla1985
Messages
91
Reaction score
0
Hi all, I have this (nondimensionalised) system of ODEs that I am trying to analyse:
\[
\begin{align}
\frac{dr}{dt}= &\ - \left(\alpha+\frac{\epsilon}{2}\right)r + \left(1-\frac{\epsilon}{2}\right)\alpha p - \alpha^2\beta r p + \frac{\epsilon}{2} \\
\frac{dp}{dt}= &\ \left(1-\frac{\epsilon}{2\alpha}\right)r - \left(1+\frac{\epsilon}{2}\right)p - \alpha\beta r p + \frac{\epsilon}{2\alpha}
\end{align}
\]
with initial conditions $r(0)=1, p(0)=0$ and $\epsilon$ is a small parameter. After substituting in the asymptotic approximations $r\approx r_0+\epsilon r_1+...$, $p\approx p_0+\epsilon p_1+...$ I get a leading order problem as
\[
\begin{align}
\frac{dr_0}{dt}= &\ - \alpha r_0 + \alpha p_0 -\alpha^2\beta r_0 p_0 \\
\frac{dp_0}{dt}= &\ r_0 - p_0 -\alpha\beta r_0 p_0
\end{align}
\]

Clearly, this is still of no help as it's still nonlinear. So my question is, is there any way of getting past this?

The only other piece of information I have is that at equilibrium the solution for both will be $O(\epsilon^{1/2})$. I did attempt to rescale for this but I then get a singular perturbation problem in which the limit of the inner solution is infinity so I could not do the matching (I will explain in more detail what I did for this if needed). If anyone could suggest a way in which I can solve this problem I would be very grateful.

Thank you!
Carla
 
Physics news on Phys.org
What are $$\alpha$$ and $$\beta$$? What we know about them?
 
The non-linearity has nothing to do with \epsilon but rather with \alpha and \beta.
 
$\alpha$ and $\beta$ are grouped parameters from how I did the nondimensionalisation. Basically the system is a type of drug-receptor binding system. After nondimensionalising I have 3 parameters: $\alpha$, $\beta$ and $\gamma$. We know that $\alpha$ is $O(1)$ but have limit information about $beta$ and $gamma$. So we are trying to use asymptotic to explore these. To do this we fix one of the parameters to also be $O(1)$ and set the other to be either small ($\epsilon$) or large ($1/\epsilon$). I have done the cases of $\beta=\epsilon$, $\beta=1/\epsilon$ and $\gamma=1/\epsilon$ without too many issues. This one that I'm having trouble with is $\gamma=\epsilon$.

I understand the answer may well be that in this situation there is nothing I can do further but I thought I would ask in case there was something else I could do with it that I wasn't aware of. Either way I appreciate the help.

Thanks
Carla
 
In that case, I'd simply use either numerical methods to find out the behaviour of the solution, or use some sort of series solution to approximate the solution.
 
Carla1985 said:
$\alpha$ and $\beta$ are grouped parameters from how I did the nondimensionalisation. Basically the system is a type of drug-receptor binding system. After nondimensionalising I have 3 parameters: $\alpha$, $\beta$ and $\gamma$. We know that $\alpha$ is $O(1)$ but have limit information about $beta$ and $gamma$. So we are trying to use asymptotic to explore these. To do this we fix one of the parameters to also be $O(1)$ and set the other to be either small ($\epsilon$) or large ($1/\epsilon$). I have done the cases of $\beta=\epsilon$, $\beta=1/\epsilon$ and $\gamma=1/\epsilon$ without too many issues. This one that I'm having trouble with is $\gamma=\epsilon$.

I understand the answer may well be that in this situation there is nothing I can do further but I thought I would ask in case there was something else I could do with it that I wasn't aware of. Either way I appreciate the help.

Thanks
Carla

In your ODEs in your OP I don't see any mention of a $\gamma$ there, where should it appear?
 

Similar threads

  • · Replies 14 ·
Replies
14
Views
3K
  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 2 ·
Replies
2
Views
954
  • · Replies 1 ·
Replies
1
Views
11K
Replies
4
Views
2K
  • · Replies 10 ·
Replies
10
Views
2K
  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 5 ·
Replies
5
Views
2K
Replies
6
Views
2K
  • · Replies 4 ·
Replies
4
Views
2K