To estimate the amount of fuel needed to launch a specific weight into space, the Tsiolkovsky rocket equation is a useful resource. The discussion highlights the complexity of fuel requirements, noting that additional fuel increases the overall fuel needed due to the extra weight. While no exact formula is provided, participants agree that a rough calculation can be derived from the equation. Understanding the relationship between payload weight and fuel mass is crucial for accurate estimations. This topic emphasizes the challenges of rocket design and fuel efficiency in space missions.